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DETERMINATION OF BINDING ENTHALPIES OF ANTHRACYCLINE DRUGS TO DNA HOST CELLS

DETERMINATION OF BINDING ENTHALPIES OF ANTHRACYCLINE DRUGS TO DNA HOST CELLS
蒽环类药物与 DNA 宿主细胞结合焓的测定
批准号：
3896190
负责人：
C P MUDD
金额：
$0.0万
依托单位：
NATIONAL CENTER FOR RESEARCH RESOURCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3896190
关键词：
DNA calorimetry chemical binding daunorubicin drug interactions stop flow technique tantalum thermodynamics

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英文摘要
After performing the first direct measurements of the drug binding enthalpies for daunomycin to DNA in the 10-20 micromolar range (where the monomeric form predominates), we extended the experiment to other anthracycline drugs. We have now studied the salt and temperature dependence of the binding enthalpies for this class of drug. With a tantalum stopped flow microcalorimeter, we were able to measure 120 of these runs per day with an uncertainty of only 3 microjoules.
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TEMPERATURE CONTROLLED CHAMBER FOR X-RAY DIFFRACTION SPECIMENS
  • 批准号：
    3959937
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    C P MUDD
  • 依托单位：
    DIVISION OF RESEARCH SERVICES
HIGH-SPEED DIFFERENTIAL STOPPED-FLOW CALORIMETER
SIGNAL CONDITIONING & DATA ACQUISITION SYSTEM FOR SLEEP DEPRIVATION STUDIES
CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS
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