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DETERMINATION OF BINDING ENTHALPIES OF ANTHRACYCLINE DRUGS TO DNA HOST CELLS

DETERMINATION OF BINDING ENTHALPIES OF ANTHRACYCLINE DRUGS TO DNA HOST CELLS
蒽环类药物与 DNA 宿主细胞结合焓的测定
批准号：
3937343
负责人：
C P MUDD
金额：
$0.0万
依托单位：
DIVISION OF RESEARCH SERVICES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3937343
关键词：
DNA anthracyclines bioengineering /biomedical engineering calorimetry chemical binding daunorubicin drug interactions heat salts stop flow technique tantalum thermodynamics

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英文摘要
The first set of measurements of the drug binding enthalpies for daunomycin to DNA in the 10-20 micromolar range (where the monomeric form predominates) have been made. These results were presented in a poster session at the 1988 meeting of the Biophysical Society. The enthalpies at these concentrations were in the 30-50 microjoule range. With a tantalum stopped flow calorimeter, we were able to measure 120 of these reactions per day with an uncertainty of only 3 microjoules. We anticipate two more sets of experiments to explore the salt and temperature dependence of the enthalpies. The experiments are being performed in collaboration with the Department of Chemistry at Rutgers University.
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TEMPERATURE CONTROLLED CHAMBER FOR X-RAY DIFFRACTION SPECIMENS
  • 批准号：
    3959937
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    C P MUDD
  • 依托单位：
    DIVISION OF RESEARCH SERVICES
HIGH-SPEED DIFFERENTIAL STOPPED-FLOW CALORIMETER
SIGNAL CONDITIONING & DATA ACQUISITION SYSTEM FOR SLEEP DEPRIVATION STUDIES
CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS
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