MEASUREMENT OF THE BINDING HEATS OF OXYGEN TO HEMOGLOBIN

氧与血红蛋白结合热的测量

• 批准号: 3916208
• 负责人: C P MUDD
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916208
• 关键词: bioengineering /biomedical engineering; calorimetry; chemical binding; hemoglobin; human tissue; mathematics; oxygen; oxyhemoglobin; saturated /unsaturated bonds; stop flow technique; tantalum

The binding of oxygen to hemoglobin is thought to be a multistep process with different rate constants for each step. With an all tantalum stopped-flow calorimeter developed earlier, we can easily measure the heat of binding of oxygen to hemoglobin. The all-tantalum system will prevent the diffusion of oxygen into the system and will allow us to measure these heats over the entire saturation range, 0-100%; preliminary measurements of the binding heat at 50% saturation are in good agreement with published values.

氧与血红蛋白的结合被认为是一个多步骤的过程