THE PHYSIOLOGICAL ROLE OF MICROGLIA IN THE BRAIN

已经对小胶质细胞进行了实验，小胶质细胞是常驻巨噬细胞 中枢神经系统是从正常人的大脑皮层中培养出来的 16 三体 (Tsl6) 小鼠。 Tsl6小鼠作为人类的动物模型 患有唐氏综合症（2l 三体）。我们发现干扰素 （α IFN）是一种细胞因子，可增加佛波醇肉豆蔻酸酯的敏感性 醋酸盐（PMA）对小胶质细胞产生超氧自由基阴离子的影响 IFN 还可以增加白细胞介素 1 (IL-1) 的产生，这是另一种 细胞因子。 Ts16 小鼠 IL-1 产量的增加更大 比正常控制。

Experiments have been performed on microglia, the resident macrophage in the central nervous system cultured from cerebral cortices of normal and trisomy 16 (Tsl6) mice. The Tsl6 mouse serves as an animal model of humans afflicted with Down's syndrome (trisomy 2l). We found that interferon (alfa IFN), a cytokine, increases the sensitivity of phorbol myristate acetate (PMA) on microglial production of the superoxide radical anion and that IFN also increases the production of interleukin-1 (IL-1), another cytokine. The increase in production of IL-1 is larger for the Ts16 mouse than for normal controls.