THE PHYSIOLOGICAL ROLE OF MICROGLIA IN THE BRAIN

在小胶质细胞上进行了实验，小胶质细胞是驻留在 大鼠大脑皮质培养的中枢神经系统 16三体(TSL6)小鼠。Tsl6小鼠是人类的动物模型 患有唐氏综合征(21三体)。我们发现干扰素 细胞因子(α-干扰素)增加佛波酯的敏感性 醋酸(PMA)对小胶质细胞产生超氧阴离子和 干扰素还会增加白介素1(IL-1)的产生，另一种 细胞因子。TS16小鼠IL-1产生的增加幅度更大 而不是正常对照组。

Experiments have been performed on microglia, the resident macrophage in the central nervous system cultured from cerebral cortices of normal and trisomy 16 (Tsl6) mice. The Tsl6 mouse serves as an animal model of humans afflicted with Down's syndrome (trisomy 2l). We found that interferon (alfa IFN), a cytokine, increases the sensitivity of phorbol myristate acetate (PMA) on microglial production of the superoxide radical anion and that IFN also increases the production of interleukin-1 (IL-1), another cytokine. The increase in production of IL-1 is larger for the Ts16 mouse than for normal controls.