THE PHYSIOLOGICAL ROLE OF MICROGLIA IN THE BRAIN

小胶质细胞在大脑中的生理作用

• 批准号: 3881697
• 负责人: D L GILBERT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3881697
• 关键词: Downs syndrome; acetates; acyl group; brain cell; central nervous system; chemotaxis; disease /disorder model; drug metabolism; electrophysiology; free radicals; genetic strain; interferon inducers; interleukin 2; ion transport; laboratory mouse; macrophage; membrane permeability; microglia; neuropharmacology; neurophysiology; neutrophil; opsonin; phorbols; superoxides; synapses; tissue /cell culture; trisomy; zymosan

Experiments have been performed on microglia, the resident macrophage in the central nervous system cultured from cerebral cortices of normal and trisomy 16 (Tsl6) mice. The Tsl6 mouse serves as an animal model of humans afflicted with Down's syndrome (trisomy 2l). We found that interferon (alfa IFN), a cytokine, increases the sensitivity of phorbol myristate acetate (PMA) on microglial production of the superoxide radical anion and that IFN also increases the production of interleukin-1 (IL-1), another cytokine. The increase in production of IL-1 is larger for the Ts16 mouse than for normal controls.

实验已经在小胶质细胞上进行，小胶质细胞是脑内的常驻巨噬细胞。 从正常人和正常人的大脑皮层培养中枢神经系统， 16三体（Tsl 6）小鼠。Tsl 6小鼠作为人类的动物模型 患有唐氏综合症（2l三体）。我们发现干扰素 (alfa干扰素），一种细胞因子，增加佛波酯的敏感性 乙酸（PMA）对小胶质细胞产生超氧阴离子自由基的影响， IFN还可以增加白细胞介素-1（IL-1）的产生， 细胞因子Ts 16小鼠IL-1产生的增加更大 而不是正常对照组。