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EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES

EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES
药物对膜中电压依赖性离子电导的影响
批准号：
3945204
负责人：
D L GILBERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3945204
关键词：
action potentials axon biophysics chemical structure function drug metabolism drug screening /evaluation free radicals gamma aminobutyrate glutamates hydrogen peroxide hydroxyl group ion transport mathematical model membrane permeability membrane potentials neural conduction neural transmission neuromuscular junction neuropharmacologic agent neuropharmacology neurotransmitter metabolism respiratory oxygen saltwater environment synapses yohimbine

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英文摘要
Experiments have been performed on microglia, the resident macrophage in central nervous system. We found that these cells have the ability to secrete the superoxide radical ion. The amount of secretion increased with an increase in the calcium concentration. Using the patch clamp technique, a calcium channel was found. The microglia can also produce an amyloid- like material.
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EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES
THE PHYSIOLOGICAL ROLE OF MICROGLIA IN THE BRAIN
SOURCES AND EFFECTS OF REACTIVE OXYGEN INTERMEDIATES IN THE BRAIN
EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES
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