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EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES

EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES
药物对膜中电压依赖性离子电导的影响
批准号：
3968931
负责人：
D L GILBERT
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968931
关键词：
action potentials axon biophysics chemical structure function drug metabolism drug screening /evaluation free radicals gamma aminobutyrate glutamates hydrogen peroxide hydroxyl group ion transport mathematical model membrane permeability membrane potentials neural conduction neural transmission neuromuscular junction neuropharmacologic agent neuropharmacology neurotransmitter metabolism respiratory oxygen saltwater environment synapses yohimbine

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英文摘要
Experiments have been performed on the effects of hydrogen peroxide, a reactive derivative of molecular oxygen, on synaptic transmission. Hydrogen peroxide effects a decrease in glutamate-mediated excitatory transmission, caused by both presynaptic and postsynaptic mechanisms. It also effects a decrease in GABA-mediated inhibitory transmission, caused by supression of the presynaptic release of GABA. A further effect of hydrogen peroxide is a reduction of short-term synaptic facilitation. These effects are somewhat different from the experimental effects of molecular oxygen, itself. Other reactive derivatives will be examined in order to elucidate the overall effect of molecular oxygen.
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EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES
SOURCES AND EFFECTS OF REACTIVE OXYGEN INTERMEDIATES IN THE BRAIN
THE PHYSIOLOGICAL ROLE OF MICROGLIA IN THE BRAIN
EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES
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