EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES

药物对膜中电压依赖性离子电导的影响

• 批准号: 3968931
• 负责人: D L GILBERT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968931
• 关键词: action potentials; axon; biophysics; chemical structure function; drug metabolism; drug screening /evaluation; free radicals; gamma aminobutyrate; glutamates; hydrogen peroxide; hydroxyl group; ion transport; mathematical model; membrane permeability; membrane potentials; neural conduction; neural transmission; neuromuscular junction; neuropharmacologic agent; neuropharmacology; neurotransmitter metabolism; respiratory oxygen; saltwater environment; synapses; yohimbine

Experiments have been performed on the effects of hydrogen peroxide, a reactive derivative of molecular oxygen, on synaptic transmission. Hydrogen peroxide effects a decrease in glutamate-mediated excitatory transmission, caused by both presynaptic and postsynaptic mechanisms. It also effects a decrease in GABA-mediated inhibitory transmission, caused by supression of the presynaptic release of GABA. A further effect of hydrogen peroxide is a reduction of short-term synaptic facilitation. These effects are somewhat different from the experimental effects of molecular oxygen, itself. Other reactive derivatives will be examined in order to elucidate the overall effect of molecular oxygen.

实验已经进行过氧化氢的影响， 分子氧的活性衍生物，突触传递。 过氧化氢影响谷氨酸介导的兴奋性降低 传递，由突触前和突触后机制引起。 它 也影响GABA介导的抑制性传递的减少， 抑制突触前GABA的释放。 的进一步效果 过氧化氢是短期突触易化的减少。 这些效应与以下实验效应有些不同： 分子氧本身 其他反应性衍生物将在 以阐明分子氧的整体效应。