EFFECT OF DRUGS ON VOLTAGE-DEPENDENT IONIC CONDUCTANCE IN MEMBRANES

药物对膜中电压依赖性离子电导的影响

• 批准号: 3922497
• 负责人: D L GILBERT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3922497
• 关键词: cell membrane; chemotaxis; drug metabolism; electrophysiology; ion transport; macrophage; membrane permeability; membrane transport proteins; microglia; neutrophil; opsonin; synapses; tissue /cell culture; zymosan

Experiments have been performed on microglia, the resident macrophage in central nervous system. There are many functional similarities between macrophages and neutrophils. We have shown the functional similarity of macroglia to neutrophils. Cultured microglia and neutrophils exhibit chemotaxis. Many substances which stimulate chemotaxis of neutrophils also stimulate chemotaxis of microglia. Culturing microglia under conditions that produce different stages of activation result in a different response to opsonized zymosan. In other experiments, we have demonstrated that the squid giant synapse is able to function for almost an hour in absence of oxygen.

实验已经在小胶质细胞上进行， 中枢神经系统巨噬细胞 有许多功能 巨噬细胞和中性粒细胞之间的相似性。 我们已经表明 大胶质细胞与中性粒细胞的功能相似性。 培养 小胶质细胞和嗜中性粒细胞表现出趋化性。 许多物质 刺激中性粒细胞的趋化性也刺激趋化性 小胶质细胞 培养小胶质细胞的条件下， 不同的激活阶段导致不同的反应， 调理素化酵母聚糖。 在其他实验中，我们已经证明， 乌贼巨大的突触能够在 没有氧气。