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ICRF-187 AND THE EFFECT ON DOXORUBICIN CARDIOMYOPATHY IN CANCER PATIENTS

ICRF-187 AND THE EFFECT ON DOXORUBICIN CARDIOMYOPATHY IN CANCER PATIENTS
ICRF-187 以及对癌症患者阿霉素心肌病的影响
批准号：
3899234
负责人：
V J FERRANS
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3899234
关键词：
antineoplastics biopsy breast neoplasms cardiotonic agents cardiotoxin doxorubicin drug adverse effect drug tolerance echocardiography human subject human therapy evaluation metastasis myocardium disorder neoplasm /cancer chemotherapy

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中文摘要
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英文摘要
In a randomized clinical trail ICRF-187 was found to provide cardiac protection (as shown by changes in echocardiographic measurements, radionuclide studies and endomyocardial biopsies) against the development of doxorubicin-induced cardiomyopathy in patients with metastatic carcinoma of the breast. This protection was exerted without significant clinical side effects and without interfering with the effectiveness of the anti-neoplastic therapy. Thus, ICRF-187 is useful in extending the therapeutic effectiveness of doxorubicin.
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