ENDOTHELIAL FENESTRATIONS OF THE ALVEOLAR CAPILLARIES IN FIBROTIC LUNG DISORDERS

纤维化肺疾病中肺泡毛细血管的内皮开窗

• 批准号: 3843448
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843448
• 关键词: biopsy; capillary; electron microscopy; histopathology; human tissue; lung alveolus; metaplasia; phenotype; pulmonary fibrosis /granuloma; respiratory epithelium; vascular endothelium permeability

Electron microscopic studies of lung biopsy specimens reveal the presence of pulmonary alveolar capillaries of the fenestrated type (containing diaphragm-like openings or fenestrae in their cytoplasm) in 20 of 28 patients with a variety of fibrotic lung disorders. Such capillaries are normally present in bronchial mucosa, but not in alveoli. Consideration is given to the possibility that this phenotypic change represents a metaplastic process analogous to that which occurs in pulmonary alveolar epithelium in fibrotic lung disorders.

肺活检标本的电子显微镜研究显示 有孔型肺泡毛细血管（含 28例中有20例细胞质中有类似于细胞膜的开口或窗孔 患有各种纤维化肺病的患者。 这种毛细血管是 通常存在于支气管粘膜，但不存在于肺泡。 考虑是 考虑到这种表型变化代表了一种可能性， 化生过程类似于发生在肺泡 纤维化肺疾病中的上皮。

项目成果

Characterization of alpha 2-adrenergic receptor subtype-specific antibodies.

α2-肾上腺素能受体亚型特异性抗体的表征。

• 发表时间: 1993
• 期刊: Molecular pharmacology
• 影响因子: 3.6
• 作者: Kurose,H;Arriza,JL;Lefkowitz,RJ
• 通讯作者: Lefkowitz,RJ