课题基金 / 基金详情

USE OF CARDIAC TROPONIN-T AS AN INDICATOR OF DOXORUBICIN INDUCED CARDIOTOXICITY

USE OF CARDIAC TROPONIN-T AS AN INDICATOR OF DOXORUBICIN INDUCED CARDIOTOXICITY
使用心肌肌钙蛋白-T 作为阿霉素引起的心脏毒性的指示剂
批准号：
6162774
负责人：
V J FERRANS
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6162774
关键词：
biomarker blood chemistry cardiotoxin dosage doxorubicin heart cell histopathology immunocytochemistry noninvasive diagnosis spontaneous hypertensive rat stainings troponin

项目摘要

项目成果

V J FERRANS的其他基金

相似基金

相关文献

中文摘要
翻译
心肌肌钙蛋白- t （cTnT）的释放作为一种生物标志物
英文摘要
The release of cardiac Troponin-T (cTnT) as a biomarker of doxorubicin-induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT, and decreased immunohistochemical staining of heart sections for this protein, were noted in SHR treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were further elevated, coincident with reduced immunohistochemical staining, in SHR given 10 to 12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
STUDIES OF THE MORPHOLOGY OF THE BIOPROSTHETIC HEART VALVES
SURGICAL PATHOLOGY OF THE CARDIOVASCULAR SYSTEM
ULTRASTRUCTURE AND FUNCTION OF THE MYOCARDIUM--AN OVERVIEW
INTRALUMINAL FIBROSIS IN FIBROTIC LUNG DISORDERS
海外基金