USE OF CARDIAC TROPONIN-T AS AN INDICATOR OF DOXORUBICIN INDUCED CARDIOTOXICITY

使用心肌肌钙蛋白-T 作为阿霉素引起的心脏毒性的指示剂

• 批准号: 6162774
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162774
• 关键词: biomarker; blood chemistry; cardiotoxin; dosage; doxorubicin; heart cell; histopathology; immunocytochemistry; noninvasive diagnosis; spontaneous hypertensive rat; stainings; troponin

The release of cardiac Troponin-T (cTnT) as a biomarker of doxorubicin-induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT, and decreased immunohistochemical staining of heart sections for this protein, were noted in SHR treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were further elevated, coincident with reduced immunohistochemical staining, in SHR given 10 to 12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.

心肌肌钙蛋白-T（cTnT）的释放作为一种生物标志物， 多柔比星诱导的慢性心脏损伤在 自发性高血压大鼠（SHR）模型。血清水平升高 心肌切片免疫组化染色减少 对于这种蛋白质，在用累积剂量的 阿霉素（7 mg/kg）仅诱导极轻微的组织学改变 在肌细胞中。cTnT浓度进一步升高， 在10 - 12 mg/kg剂量组SHR中，免疫组织化学染色减少 阿霉素 因此，监测血清cTnT水平可以检测阿霉素诱导的 心肌细胞损伤，并可能被证明是有用的非侵入性 对人体的毒性评价。