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MORPHOGENESIS OF ABNORMAL ELASTIC FIBERS IN EMPHYSEMA

MORPHOGENESIS OF ABNORMAL ELASTIC FIBERS IN EMPHYSEMA
肺气肿中异常弹性纤维的形态发生
批准号：
3879029
负责人：
V J FERRANS
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3879029
关键词：
elastin emphysema human tissue hydrolysis immunocytochemistry immunoelectron microscopy morphology pathology

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中文摘要
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英文摘要
Morphologic and immunohistochemical studies at the electron microscopic level were made of elastic fibers in lung of four patients with pulmonary emphysema. Abnormal elastic fibers were observed which were interpreted as resulting from: 1) hydrolytic damage by elastase and 2) abnormal synthesis of new elastic fibers in areas of pulmonary remodeling. These observations emphasize the critical importance of alterations of elastic fibers in the pathogenesis of pulmonary emphysema.
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