MORPHOGENESIS OF ABNORMAL ELASTIC FIBERS IN EMPHYSEMA

肺气肿中异常弹性纤维的形态发生

• 批准号: 3879029
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3879029
• 关键词: elastin; emphysema; human tissue; hydrolysis; immunocytochemistry; immunoelectron microscopy; morphology; pathology

Morphologic and immunohistochemical studies at the electron microscopic level were made of elastic fibers in lung of four patients with pulmonary emphysema. Abnormal elastic fibers were observed which were interpreted as resulting from: 1) hydrolytic damage by elastase and 2) abnormal synthesis of new elastic fibers in areas of pulmonary remodeling. These observations emphasize the critical importance of alterations of elastic fibers in the pathogenesis of pulmonary emphysema.

电子显微镜的形态和免疫组织化学研究 4例肺心病患者肺组织弹性纤维水平的研究 肺气肿。观察到异常的弹性纤维，这被解释为 原因：1)弹性酶的水解性损伤和2)合成异常 肺重塑区域的新弹性纤维。这些观察结果 强调弹性纤维变化的关键重要性 肺气肿的发病机制。