EVALUATION OF ACUTE AND CHRONIC CARDIOTOXICITY IN MINIATURE SWINE

小型猪急性和慢性心脏毒性的评价

• 批准号: 3942924
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942924
• 关键词: cardiotoxin; disease /disorder model; doxorubicin; drug screening /evaluation; minoxidil

An evaluation was made of the suitability of miniature swine as animal models for the morphologic assessment of changes related to the acute and the chronic cardiotoxicity produced by pharmacologic agents. Minoxidil and doxorubicin were used as experimental agents capable of producing acute and chronic cardiotoxicity, respectively. The results obtained show that miniature swine are useful models to study both types of cardiotoxicity.

本文对小型猪作为小型猪饲料的适宜性进行了评价。 用于形态学评估相关变化的动物模型 对急性和慢性心脏毒性的影响 药物制剂。 米诺地尔和阿霉素被用作 能够产生急性和慢性 心脏毒性。 所获得的结果显示 小型猪是研究这两种类型的有用模型。 心脏毒性