MODELS IN THE MONKEY OF GENERALIZED SEIZURES OF THE ABSENCE TYPE

缺席型广义癫痫发作的猴子模型

• 批准号: 3900955
• 负责人: A F MIRSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3900955
• 关键词: Macaca mulatta; attention; brain disorder diagnosis; brain electrical activity; brain stem; convulsants; disease /disorder model; electrostimulus; frontal lobe /cortex; gamma aminobutyrate; generalized seizures; model design /development; neural information processing; neuropharmacology; neurophysiology; occipital lobe /cortex; parietal lobe /cortex; sensory feedback; stimulant /agonist

Generalized seizure activity with the electrographic appearance of absence epilepsy (bilaterally symmetrical and synchronous paroxysmal three-per-second spike and wave discharger can be elicited in the monkey by a variety of methods. These include electrical stimulation of various locations within the brain, injection of convulsant drugs and other substances, and administration of compounds which may alter normal inhibitory mechanisms within the cell. Model seizure states created in these ways are studied in order to test hypotheses about pathophysiological seizure mechanisms, sensory processing and attentional capacities during absence seizures, effects of spike-wave activity on cellular activity, and effects of techniques or maneuvers which may modify or reduce convulsive activity. Most recently this project has involved the following work: we studied the behavioral and electrographic effects of a GABA-enhancer and surveyed the attention-related cells in the frontal lobes of the monkey. Other studies of "attention" cells in inferior parietal and preoccipital cortex have been completed as well.

全身性癫痫发作，电图表现为失神状态 癫痫（双侧对称性和同步性阵发性 可以通过以下方式在猴子体内引出每秒三个尖峰和波放电器 多种方法。 这些包括各种电刺激 大脑内的位置、注射惊厥药物和其他 物质和可能改变正常的化合物的施用 细胞内的抑制机制。 模型癫痫发作状态创建于 研究这些方法是为了检验有关病理生理学的假设 癫痫发作机制、感觉处理和注意力能力 失神发作、棘波活动对细胞活动的影响，以及 可能改变或减少惊厥的技术或动作的效果 活动。 最近该项目涉及以下工作：我们 研究了 GABA 增强剂的行为和电图效应， 研究人员调查了猴子额叶中与注意力相关的细胞。 下顶叶和枕前叶“注意”细胞的其他研究 皮质也已完成。