ATTENTION DISORDERS AS ASSESSED BY EVENT-RELATED BRAIN POTENTIALS

这个项目的目的是研究大脑的作用。 事件相关电位注意与信息加工及其机制 精神科疾病的病因、病理和预后的相互关系 和神经性疾病。主要强调的是诊断的特异性 注意和认知障碍与认知障碍的识别 观察到的信息处理的特定方面或阶段 性能下降。同时记录的脑事件相关事件 认知任务的潜能和表现被用来区分 有诊断的受试者注意机制障碍的模式 季节性情感障碍，精神分裂症发作，饮食失调， 阅读障碍，闭合性头部损伤，注意力缺陷多动障碍，以及 多发性抽动症。该项目的一个相关目标是 区分这些疾病的状态和特征属性以增加 对其病因的理解。脑事件相关电位也是 用来研究改变的神经化学机制的作用 比较药物诱导的电生理和行为效应与 在各种疾病中出现的那些。大脑事件之间的相关性-- 相关电位和神经成像(磁共振成像)数据为 用于研究信息处理指标之间的关系 以及与脑部病理生理学有关的脑区体积 精神分裂症。心理上的相关因素是通过将 广泛的神经心理学、精神病学和人格测量的数据 以及在行为任务上的表现。

The aim of this project is to investigate the role of brain event-related potentials attention, and information processing and their interrelationships in the etiology- pathology, and prognosis of psychiatric and neurological disorders. Major emphasis is on the diagnostic specificity of disorders of attention and cognition and the identification of the specific aspects or stages of information processing underlying observed decrements in performance. Concurrently recorded brain event-related potentials and performance on cognitive tasks are used to differentiate patterns of dysfunction in attentive mechanisms in subjects with diagnoses of seasonal affective disorder, schizophrenia seizures, eating disorders, dyslexia, closed head injury, attention deficit hyperactivity disorder, and Tourette's disorder. A related objective of this project is to differentiate state versus trait attributes of these disorders to increase understanding of their etiologies. Brain event-related potentials are also used to investigate the role of altered neurochemical mechanisms by comparing drug-induced electrophysiological and behavioral effects with those seen in the various disorders. Correlations between brain event-- related potentials and neuroimaging (magnetic resonance imaging) data are used to study the relationship between indices of information processing and the volume of brain regions implicated in the pathophysiology of schizophrenia. Psychological correlates are investigated by relating the data to extensive neuropsychological, psychiatric, and personality measures as well as to performance on behavioral tasks.