ATTENTION DISORDERS AS ASSESSED BY EVENT-RELATED BRAIN POTENTIALS

通过事件相关的大脑电位评估注意力障碍

• 批准号: 5203667
• 负责人: A F MIRSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5203667
• 关键词: Tourette's syndrome; attention; attention deficit disorder; behavior test; brain electrical activity; brain injury; child (0-11); cognition disorders; eating disorders; electrophysiology; epilepsy; evoked potentials; human subject; magnetic resonance imaging; mental disorder diagnosis; mental disorders; nervous system disorder; neural information processing; neurochemistry; neuropsychology; psychophysiology; reading disorder; schizophrenia; seasonal affective disorder

The aim of this project is to investigate the roles of brain event- related potential, and prognosis of psychiatric and neurological disorders. Major emphasis is on the diagnostic specificity of disorders of attention and cognition and the identification of the specific aspects or stages of information processing underlying observed decrements in performance. Concurrently recorded brain event-related potentials and performance on cognitive tasks are used to differentiate patterns of dysfunction in attentive mechanism in subjects with diagnoses of schizophrenia, seizures, seasonal affective disorder, eating disorders, dyslexia, closed head injury, attention deficit hyperactivity disorder, and Tourette's disorder. A related objective of this project is to differentiate state versus trait attributes of these disorders to increase understanding of their etiologies. Brain event-related potentials are also used to investigate the role of altered neurochemical mechanisms by comparing drug-induced eletrophysiological and behavioral effects with those seen in the various disorder. Correlations between brain event-related potentials and neuroimaging(magnetic resonance imaging) data are used to study the relationship between indices of information processing and the volume of brain regions implicated in the pathophysiology of schizophrenia. Psychological correlates are investigated by relating the data to extensive neuropsychological, psychiatric, and personality measures as well as to performance on behavioral tasks.

这个项目的目的是研究大脑事件的作用- 相关电位与精神病学和神经病学的预后 精神错乱。主要强调疾病的诊断特异性。 注意力和认知力以及对特定方面的识别 或根据观察到的减量的信息处理阶段 性能。同时记录的脑事件相关电位和 在认知任务上的表现被用来区分 精神分裂症患者注意机制障碍的研究 精神分裂症，癫痫，季节性情感障碍，饮食失调， 阅读障碍，闭合性头部损伤，注意缺陷多动障碍， 以及多发性抽动症。该项目的一个相关目标是 区分这些疾病的状态和特征属性以 增加对其病因的了解。脑事件相关 电位也被用来研究改变的神经化学物质的作用。 药物诱发的电生理和行为学机制的比较 对那些在各种疾病中看到的影响。两者之间的相关性 脑事件相关电位和神经成像(磁共振 成像)数据用于研究各指标之间的关系 信息加工与脑区体积的关系 精神分裂症的病理生理学。相关的心理因素有 通过将数据与广泛的神经心理学联系起来进行调查， 精神病学和人格测量，以及在 行为任务。