MODELS IN THE MONKEY OF GENERALIZED SEIZURES OF THE ABSENCE TYPE

缺席型广义癫痫发作的猴子模型

• 批准号: 4696352
• 负责人: A F MIRSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696352
• 关键词: aminoacid inhibitor; attention; brain electrical activity; brain stem; convulsants; disease /disorder model; electrostimulus; evoked potentials; gamma aminobutyrate; generalized seizures; nervous system disorder diagnosis; neural information processing; neuropharmacology; neurophysiology; pathologic process; pentylenetetrazole

Generalized seizure activity with the electrographic appearance of absence epilepsy (bilaterally symmetrical and synchronous paroxysmal three-per-second spike and wave discharges) can be elicited in the monkey by a variety of methods. These include electrical stimulation of various locations within the brain, injection of convulsant drugs and other substances, and administration of compounds which may alter normal inhibitory mechanisms within the cell. Model seizure states created in these ways are studied in order to test hypotheses about pathophysiological seizure mechanisms, sensory processing and attentional capacities during absence seizures, effects of spike-wave activity on cellular activity, and effects of techniques or maneuvers which may modify or reduce convulsive activity. Most recently this project has involved the following work: we studied the (paradoxical) seizure-inducing effects of a GABA-enhancer and the effects of auditory brain stem evoked potentials of generalized seizures induced by injection of pentylenetetrazol.

全身性惊厥活动伴失神的心电图表现 癫痫(双侧对称和同步发作 每秒三次的尖峰和波的放电)可以在猴子身上诱发 通过各种方法。这些包括各种电刺激 大脑内的位置，注射惊厥药物和其他 物质，以及可能改变正常状态的化合物的服用 细胞内的抑制机制。在中创建的模型发作状态 研究这些方法是为了检验有关病理生理学的假说。 癫痫发作机制、感觉加工和注意能力 失神发作，棘波活动对细胞活动的影响，以及 可改变或减少抽搐的技术或动作的效果 活动。最近，该项目涉及以下工作：我们 研究了一种GABA增强剂的(矛盾的)癫痫诱导效应和 广泛性听性脑干诱发电位的影响 注射戊四氮诱发癫痫发作。