ATTENTION DISORDERS AS ASSESSED BY EVENT-RELATED BRAIN POTENTIALS

通过事件相关的大脑电位评估注意力障碍

• 批准号: 3859836
• 负责人: A F MIRSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859836
• 关键词: Tourette's syndrome; attention; attention deficit disorder; brain electrical activity; brain injury; cognition disorders; electrical potential; electrophysiology; epilepsy; human subject; magnetic resonance imaging; mental disorder diagnosis; mental disorders; nervous system disorder; neural information processing; neurochemistry; prognosis; reading disorder; schizophrenia; seasonal affective disorder

The aim of this project is to investigate the roles of brain event-related potentials, attention, and information processing and their interrelationships in the etiology, pathology, and prognosis of psychiatric and neurological disorders. Major emphasis is on the diagnostic specificity of disorders of attention and cognition and the identification of the specific aspects or stages of information processing underlying observed decrements in performance. Concurrently recorded brain event- related potentials and performance on cognitive tasks are used to differentiate patterns of dysfunction in attentive mechanisms in subjects with diagnoses of seasonal affective disorder, schizophrenia, seizures, eating disorders, dyslexia, closed head injury, attention deficit hyperactivity disorder, and Tourette's disorder. A related objective of this project is to differentiate state versus trait attributes of these disorders to increase understanding of their etiologies. Brain event- related potentials are also used to investigate the role of altered neurochemical mechanisms by comparing drug-induced electrophysiological and behavioral effects with those seen in the various disorders. Correlations between brain event-related potentials and neuroimaging (magnetic resonance imaging) data are used to study the relationship between indices of information processing and the volume of brain regions implicated in the pathophysiology of schizophrenia. Psychological correlates are investigated by relating the data to extensive neuropsychological, psychiatric, and personality measures as well as to performance on behavioral tasks.

本项目的目的是研究脑事件相关的 潜力、注意力和信息处理及其 精神疾病的病因、病理和预后的相互关系 和神经紊乱。 主要强调的是诊断 注意和认知障碍的特异性及其鉴别 信息处理的具体方面或阶段 观察到性能下降。 同时记录的大脑活动- 相关电位和认知任务的表现被用来 区分受试者注意机制的功能障碍模式 被诊断为季节性情感障碍精神分裂症癫痫 进食障碍、阅读障碍、闭合性脑损伤、注意力缺陷 多动症和图雷特氏症 一个相关的目标， 这个项目是为了区分状态与特质属性，这些 以增加对其病因的理解。 脑事件- 相关电位也被用来研究改变的作用。 通过比较药物诱导的电生理和神经化学机制， 行为效应与各种疾病中的行为效应相同。 相关性 脑事件相关电位和神经成像（磁共振）之间的关系 成像）数据用于研究指标之间的关系 信息处理和涉及的大脑区域的体积 精神分裂症的病理生理学 心理相关因素包括 通过将数据与广泛的神经心理学相关联进行调查， 精神和人格的措施，以及性能 行为任务