MODELS IN THE MONKEY OF GENERALIZED SEIZURES OF THE ABSENCE TYPE

缺席型广义癫痫发作的猴子模型

• 批准号: 3921879
• 负责人: A F MIRSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921879
• 关键词: Macaca mulatta; attention; brain disorder diagnosis; brain electrical activity; brain stem; convulsants; disease /disorder model; electrostimulus; frontal lobe /cortex; gamma aminobutyrate; generalized seizures; model design /development; neural information processing; neuropharmacology; neurophysiology; occipital lobe /cortex; parietal lobe /cortex; pathologic process; sensory feedback

Generalized seizure activity with the electrographic appearance of absence epilepsy (bilaterally symmetrical and synchronous paroxysmal three-per-second spike and wave discharges) can be elicited in the monkey by a variety of methods. These include electrical stimulation of various locations within the brain, injection of convulsant drugs and other substances, and administration of compounds which may alter normal inhibitory mechanisms within the cell. Model seizure states created in these ways are studied in order to test hypotheses about pathophysiological seizure mechanisms, sensory processing and attentional capacities during absence seizures, effects of spike- wave activity on cellular activity, and effects of techniques or maneuvers which may modify or reduce convulsive activity. Most recently this project has involved the following work: we studied the behavioral and electrographic effects of a GABA-enhancer and surveyed the attention-related cells in the frontal lobes of the monkey. Other studies of "attention" cells in inferior parietal and preoccipital cortex have been completed as well.

全身性癫痫发作，电图表现为 失神性癫痫（双侧对称和同步 阵发性每秒三次尖峰和波放电）， 通过各种方法在猴子身上激发。 这些包括 对大脑内不同位置的电刺激， 注射致惊厥药物和其他物质，以及 给药可改变正常抑制性的化合物 细胞内的机制。 在这些国家中创建的模型癫痫发作状态 方法进行了研究，以测试假设， 病理生理癫痫发作机制，感觉处理和 注意力的能力，在失神发作，影响的尖峰， 波活动对细胞活动的影响，以及技术或 可能改变或减少抽搐活动的动作。 最 最近，该项目涉及以下工作：我们研究了 GABA增强剂的行为和电图效应， 调查了大脑额叶中与注意力相关的细胞， 猴子. 下顶叶中“注意”细胞的其他研究 和前枕叶皮层也完成了