DERMAL ABSORPTION OF DIETHANOLAMINE AND TRIETHANOLAMINE IN RATS AND MICE

二乙醇胺（DEA）和三乙醇胺（TEA）广泛用于 化妆品，如面霜、皮肤清洁剂和洗发水。在一个14- 由国家毒理学计划（TEA）进行的一天重复给药研究 经皮肤给药后，发现对大鼠皮肤的毒性大于小鼠 应用程序. TEA在f344大鼠和B6 C3 F1中的皮肤吸收研究 小鼠开始帮助解释敏感性的物种差异 这个化学品。剪下雄性大鼠和小鼠肩胛间区， 并将筛选环安装在化学品的预定位置上 应用程序.将溶解在丙酮中的14 C-TEA施加到组织内 给大鼠和小鼠戴帽子。在8个时间点采集血样， 给药后48小时，氧化为CO2，并通过 液体闪烁计数尿液、粪便、组织帽中的放射性 并对来自施用部位的皮肤切片进行计数。茶 大鼠和小鼠皮肤给药后吸收;然而， 吸收在小鼠中更大，化学品的水平保留在 在大鼠中的应用部位更大。相似比较真皮 计划在大鼠和小鼠中进行DEA的吸收研究。

Diethanolamine (DEA) and triethanolamine (TEA) are widely used in cosmetic products such as creams, skin cleaners, and shampoos. In a 14- day repeated-dose study conducted by the National Toxicology Program, TEA was found to be more toxic to the skin of rats than mice after dermal application. Dermal absorption studies of TEA in f344 rats and B6C3F1 mice were initiated to help explain species differences in sensitivity to this chemical. The interscapular are of male rats and mice were clipped, and screened rings were mounted over the intended site of chemical application. 14C-TEA dissolved in acetone was applied within the tissue caps to rats and mice. Blood samples were taken at eight time points over a 48 hour period after dosing, oxidized to CO2 and assayed for 14C by liquid scintillation counting. Radioactivity in urine, feces, tissue caps and skin sections from the site of application were also counted. Tea was absorbed after dermal application in rats and mice; however, the rate of absorption was greater in mice and the level of chemical retained at the site of application was greater in rats. Similar comparative dermal absorption studies of DEA in rats and mice are planned.