TOXIC EFFECTS OF 1,2-DIBROMO-3-CHLOROPROPANE ON THE UROGENITAL SYSTEM

1,2-二溴-3-氯丙烷对泌尿生殖系统的毒性作用

• 批准号: 4693212
• 负责人: R L MELNICK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693212
• 关键词: animal age group; chlorohydrocarbon insecticide; cytotoxicity; dosage; environmental contamination; environmental toxicology; hepatotoxin; insecticide biological effect; kidney function; liver metabolism; renal toxin; reproductive system; spermicide; toxin metabolism; urinary tract

The acute and subchronic toxic effects of the pesticide 1,2-dibromo-3-chloropropane (DBCP) and structurally-related compounds are studied from functional and mechanistic viewpoints. A reported chemo-sterilant in humans, DBCP is no longer manufactured in the U.S., but its presence in ground water and on edible imports and its illegal bulk transport into certain areas of the U.S. require its further toxicological characterization. Effects of DBCP on hepatic, renal, and reproductive functions and development are evaluated at several dose levels, after various treatment regimens and under differing conditions such as age, chemical or physical stress and the like. The mechanism of DBCP inhibition of sperm energy metabolism is being investigated.

农药的急性和亚慢性毒性作用 1，2-二溴-3-氯丙烷（DBCP）和结构相关的化合物， 从功能和机械的角度进行研究。 据报道 在人类中使用化学绝育剂，DBCP不再在美国生产，但 其存在于地下水和进口食品中， 运输到美国的某些地区需要进一步的毒理学 特征化 二溴氯丙烷对肝脏、肾脏和生殖系统的影响 在几个剂量水平下评价功能和发育， 各种治疗方案和在不同的条件下如年龄， 化学或物理应力等。 二溴氯丙烷抑制精子能量代谢的机制尚不清楚 研究了