BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS

微囊化学品的生物利用度和毒性研究

基本信息

项目摘要

The National Toxicology Program is exploring the feasibility of adopting microencapsulation as an alternative means of incorporating volatile, reactive, and/or unpalatable chemicals into animal feed for toxicologic studies. Oral (dosed-feed) toxicology studies are performed on those chemicals which are demonstrated to be adequately stabilized in the microcapsules, but released into the gastrointestinal tract to allow biological availability. The absorption of trichloroethylene (TCE), stabilized in gelatin- sorbitol microcapsules, was equivalent to that of neat TCE dissolved in corn oil when administered by gavage to Fischer 344 rats. In a 14-day repeated-dose study in F344 rats, similar toxic effects were produced by microencapsulated TCE given in feed as TCE dissolved in corn oil administered by gavage. These studies indicate that microencapsulation can provide an excellent alternative method for studying the oral toxicological properties of volatile chemicals in laboratory animals. 2-Ethylhexanol (2- EH) was stabilized in a starch matrix-type microcapsule. Bioequivalence studies have demonstrated that 2-EH is similarly absorbed after gavage administration of corn oil suspensions of microencapsulated 2-EH or neat 2-EH dissolved in corn oil. Future work will involve bioequivalence studies and toxicologic characterization of other microencapsulated chemicals.
国家毒理学计划正在探索的可行性

项目成果

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R L MELNICK其他文献

R L MELNICK的其他文献

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{{ truncateString('R L MELNICK', 18)}}的其他基金

MECHANISM OF DI(2-ETHYLHEXYL)PHTHALATE HEPATOTOXICITY
邻苯二甲酸二(2-乙基己基)酯的肝毒性机制
  • 批准号:
    3941487
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MECHANISM OF DI(2-ETHYLHEXYL)PHTHALATE HEPATOTOXICITY
邻苯二甲酸二(2-乙基己基)酯的肝毒性机制
  • 批准号:
    4693194
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS
微囊化学品的生物利用度和毒性研究
  • 批准号:
    3918626
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
TOXICOKINETIC AND BIOCHEMICAL MODELING OF HAZARDOUOS AGENTS
危险物质的毒代动力学和生化模型
  • 批准号:
    6162326
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MECHANISTIC STUDIES ON 1,3-BUTADIENE AND RELATED EPOXIDE-FORMING CHEMICALS
1,3-丁二烯及相关环氧化物形成化学品的机理研究
  • 批准号:
    6162329
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MECHANISMS OF PHTHALATE ESTER TOXICITIES IN MAMMALIAN SPECIES
哺乳动物中邻苯二甲酸酯的毒性机制
  • 批准号:
    3965202
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
TOXIC EFFECTS OF 1,2-DIBROMO-3-CHLOROPROPANE ON THE UROGENITAL SYSTEM
1,2-二溴-3-氯丙烷对泌尿生殖系统的毒性作用
  • 批准号:
    4693212
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MECHANISM OF DI(2-ETHYLHEXYL)PHTHALATE HEPATOTOXICITY
邻苯二甲酸二(2-乙基己基)酯的肝毒性机制
  • 批准号:
    3898088
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
DERMAL ABSORPTION OF DIETHANOLAMINE AND TRIETHANOLAMINE IN RATS AND MICE
大鼠和小鼠对二乙醇胺和三乙醇胺的皮肤吸收
  • 批准号:
    3898094
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PALATABILITY/TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS
微胶囊化化学品的适口性/毒性研究
  • 批准号:
    3898087
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
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