MECHANISMS OF PHTHALATE ESTER TOXICITIES IN MAMMALIAN SPECIES

哺乳动物中邻苯二甲酸酯的毒性机制

• 批准号: 3965202
• 负责人: R L MELNICK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965202
• 关键词: chemical carcinogenesis; diethylhexylphthalate; dosage; environmental toxicology; hepatotoxin; plastics; spermicide; teratogens; toxin metabolism; zinc

Phthalate esters are plasticizers incorporated into nearly all plastic materials. The biochemical and ultrastructural effects of di(2-ethylhexyl)phthalate (DEHP) and related chemicals are being studied to assess potential mechanisms of phthalate ester toxicity. Since DEHP and other phthalates are also male chemosterilants and teratogenic in mice, studies are being conducted to determine the role of zinc in the pathophysiology of these reproductive effects and to discern no-observed toxic effect levels.

邻苯二甲酸酯是增塑剂， 塑料材料。 生化和超微结构 邻苯二甲酸二（2-乙基己基）酯（DEHP）和相关物质的影响 正在研究化学品，以评估 邻苯二甲酸酯毒性。 由于DEHP和其他邻苯二甲酸盐也是男性化学不育剂 和致畸性，正在进行研究， 确定锌在这些病理生理学中的作用， 生殖影响和辨别未观察到的毒性作用 程度.