TOXICOKINETIC AND BIOCHEMICAL MODELING OF HAZARDOUOS AGENTS

危险物质的毒代动力学和生化模型

• 批准号: 6162326
• 负责人: R L MELNICK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162326
• 关键词: biotransformation; chemical models; chemical structure function; drug /agent; drug adverse effect; drug metabolism; model design /development; pharmacokinetics; toxicology

Summary of Work: This project is designed to characterize parameters of dose, distribution, metabolism, and elimination of xenobiotic materials. This information can aid in the design and interpretation of toxicology studies and to strengthen the scientific basis for low-dose extrapolation of risk to humans. Furthermore, biologically realistic biomathematical models provide a rigorous structure to formulate and test hypotheses on mechanisms of action of environmental hazards. Toxicokinetic models can also be adapted to different routes of exposure and dosage regimens and can accomodate factors that contribute to interindividual variabilities. During the past fiscal year, toxicokinetic models have been created, partially developed, or expanded upon for several chemicals, including primidone and its metabolite phenobarbital, isoprene, isobutene, 1,3-butadiene, TCDD, AIDS drugs singly and in combinations, melatonin, and the disposition of inhaled mercury vapor in pregnant rats and neonates.

工作概述：本项目旨在表征