PALATABILITY/TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS

微胶囊化化学品的适口性/毒性研究

• 批准号: 3898087
• 负责人: R L MELNICK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3898087
• 关键词: acyl coA dehydrogenases; amines; animal food; dosage forms; drug administration routes; drug delivery systems; gastrointestinal toxin absorption; laboratory mouse; laboratory rat; pharmacokinetics; toxicant interaction; toxicant screening; toxin metabolism; trichloroethylene; vegetable oils

The National Toxicology Program has been exploring the feasibility of adopting microencapsulation for toxicology studies as a more practical and natural method of exposing laboratory animals to volatile, reactive, and/or unpalatable chemicals. In a previous dosed feed study of microencapsulated 2-ethylhexanol in Fischer 344 rats, the compound was stable in feed, and consumed at doses which are sufficient for toxicologic evaluations. Because the microencapsulation of 2-ethylhexanol did not interfere with its absorption in rats, it was concluded that this technique would be a suitable alternative for studying the oral toxicological properties of volatile chemicals in laboratory animals. A feed study of microencapsulated 2-ethylhexanol in B6C3F1 mice was performed this year. Although feed spillage by mice (probably due to the palatability of the feed mixture) prevented a determination of the actual dose received, a treatment-related increase in the activity of peroxisomal acyl CoA oxidase activity was observed.

国家毒理学计划一直在探索 采用微胶囊进行毒理学研究， 和自然的方法将实验室动物暴露于挥发性的，反应性的， 和/或难吃的化学物质。在之前的一项给药饲料研究中， 微囊化2-乙基己醇在Fischer 344大鼠中，化合物 在饲料中稳定，并以足以 毒理学评价因为2-乙基己醇的微胶囊化 不干扰其在大鼠中的吸收，因此得出结论， 技术将是一个合适的替代研究口腔 挥发性化学品在实验室动物中的毒理学特性。一 对B6 C3 F1小鼠进行了微囊化2-乙基己醇的喂养研究。 今年演出的。尽管小鼠的饲料溢出（可能是由于 饲料混合物的适口性）阻止了实际 接受的剂量，治疗相关的活性增加 观察过氧化物酶体酰基辅酶A氧化酶活性。