Quantitative multi-modal optical imaging of deep tissue

深层组织定量多模态光学成像

• 批准号: DP150104660
• 负责人: Prof Robert McLaughlin
• 金额: $ 24.5万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104660
• 关键词: Quantitative; multi; modal; optical; imaging

This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.

该项目旨在创建新的工具来量化组织的结构和功能特性。这些工具将多种光学成像技术（多模态）结合到一个单一的、可扩展的探针中，可以使生理学家和生物医学研究人员对疾病有新的认识。将高度膨胀的探针封装在医用针内旨在允许将“针式探针”深深插入组织中，将光学成像扩展到先前不可及的区域。该项目可以开发新的量化模型，以便进行纵向评估和比较。通过使用特定的生物标志物验证这些工具，它可以提供乳腺癌和肝癌的结果，并为探索其他疾病提供框架。