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THE CONVERSION OF PHENYLALANINE TO TYROSINE

THE CONVERSION OF PHENYLALANINE TO TYROSINE
苯丙氨酸转化为酪氨酸
批准号：
3921904
负责人：
S KAUFMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3921904
关键词：
5 hydroxytryptophan aminoacid metabolism blood chemistry chemical structure function dihydroxyphenylalanine enzyme induction /repression enzyme mechanism enzyme structure enzyme substrate hepatocellular carcinoma hydroxylation hyperphenylalaninemia inborn metabolism disorder diagnosis isozymes kidney metabolism laboratory rat molecular pathology neoplastic cell culture for noncancer research neurochemistry neurotransmitter metabolism nutrition related tag phenylalanine phenylalanine 4 monooxygenase phenylketonurias phosphorylation pteridines tyrosine urinalysis

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中文摘要
翻译
为了使苯丙氨酸羟基酶完全催化 非偶联反应，酶必须高度激活，它必须 有底物类似物，如酪氨酸，占据 催化点。 纯苯丙氨酸羟基酶催化的反常反应 对甲基苯丙氨酸羟基化合成对羟甲基丙氨酸 苯丙氨酸。速率限制步骤与以下情况不同 苯丙氨酸的羟基化。 肝癌细胞中的苯丙氨酸羟基酶处于高度 激活状态。
英文摘要
In order for phenylalanine hydroxylase to catalyze a fully uncoupled reaction, the enzyme must be highly activated and it must have a substrate analogue, such as tyrosine, occupying the catalytic site. Pure phenylalanine hydroxylase catalyzes the unusual reaction of hydroxylation of p-methyl-phenylalanine to p-hydroxymethyl- phenylalanine. The rate-limiting step is not the same as it is for the hydroxylation of phenylalanine. Phenylalanine hydroxylase in hepatoma cells is in a highly activated state.
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SYNTHESIS AND RELEASE OF BIOGENIC AMINES
BIOSYNTHESIS OF CATECHOLAMINES
THE CONVERSION OF PHENYLALANINE TO TYROSINE
PHENYLKETONURIA & OTHER DISEASES CAUSED BY DEFECTS IN BIOPTERIN-DEPENDENT ENZYMES