EPILEPSY NEUROEPIDEMIOLOGY

癫痫神经流行病学

• 批准号: 3922599
• 负责人: J H ELLENBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3922599
• 关键词: case history; child (0-11); disease /disorder proneness /risk; early diagnosis; epilepsy; febrile seizure; human subject; interview; linkage mapping; nervous system disorder chemotherapy; nervous system disorder diagnosis; nervous system disorder epidemiology; newborn human (0-6 weeks); patient /disease registry; pregnancy disorder

The record-linkage system available for residents of Rochester, Minnesota has been used to identify all possible cases of complex partial, absence, and tonic-clonic seizures diagnosed between the years 1935 and 1979 who were born in the community. Case-control studies were conducted to identify risk factors associated with these seizure types. Several studies on convulsive disorders are being planned and tested for feasibility, or in progress. A protocol is in preparation for a clinical study of the Lennox-Gastaut syndrome (LGS), a severe childhood epileptic encephalopathy with significant morbidity and mortality, characterized by uncontrolled seizures, mental retardation, and possible mental deterioration, to define the pathophysiology and anatomic locus of disturbance in LGS. A descriptive and analytic study of neonatal seizures in a large military database is underway. Data are available for all singleton livebirths in military hospitals for a four-year period, a database including 375,310 infants. The occurrence of seizures in the nursery period in these infants and information on maternal and birth factors forms the basis for the study of these characteristics as predictors of neonatal seizures. We are evaluating the feasibility of performing a randomized and placebo controlled clinical trial of treatment after an initial convulsion in subjects presenting for care to the Beijing Tiantan Hospital.

罗切斯特居民可用的记录链接系统， 明尼苏达州已被用来确定所有可能的情况下，复杂的 部分性、失神性和强直阵挛性癫痫发作， 1935年和1979年出生于该社区。 病例对照 进行了研究，以确定与 这些癫痫类型 目前正在计划进行几项关于惊厥性疾病的研究， 测试可行性，或正在进行中。 一个协议是在 Lennox-Gastaut综合征临床研究的准备 (LGS)严重的儿童癫痫性脑病， 发病率和死亡率，以不受控制的癫痫发作为特征， 精神发育迟滞，以及可能的精神退化， LGS障碍的病理生理和解剖部位。 一 一个大的新生儿癫痫发作的描述和分析研究 军事数据库正在建设中。 数据可供所有人使用 在军队医院进行为期四年的单胎活产， 一个包含375,310名婴儿的数据库。 发作出现的 在这些婴儿的托儿所期间， 而出生因素构成了这些研究的基础 特征作为新生儿癫痫发作的预测因子。 我们 评价进行随机化和安慰剂治疗的可行性 在最初惊厥后治疗的对照临床试验 在北京天坛医院就诊的受试者中。