STATISTICAL COLLABORATION AND CONSULTATION

该项目包括广泛的统计合作和 与以下部门的实验室和分支机构进行协商 内部研究(DIR)，以及与外部其他神经科学单位 国家卫生研究院。特别考虑到统计规划和设计 实验、数据统计分析、统计推断。 目前研究的例子包括：生物等效性的临床试验 天然和重组α-甘露糖终止的葡萄糖脑苷酶 维拉帕米治疗患者的来源、临床病程和长期结果 Ceredase/TM在高谢病中的骨骼反应评价 Ceredase/TM纵向方案治疗高雪氏病 Fabry病的临床病程研究(DMNB)；临床试验 非氨基甲酸酯治疗难治性复杂部分性癫痫， 最后一次发作的时间和发作类型对癫痫发作的影响 PET测量的代谢变化，癫痫进展到的研究 全面性强直阵挛发作(ERB)；临床试验 环孢素对复发-缓解型多发性硬化症病变发展的影响，模型 复发缓解型多发性硬化症皮损复发的临床研究 复发-缓解期多发性硬化症的病变发展，监测MRI T2加权 复发-缓解型多发性硬化症的影像检查；B7：CD作用的测定 28-CTLA-4相互作用在慢性复发性EAE中的作用 复发缓解期患者脑白质积聚的研究 MS(NIB)；纳瓦霍部落神经系统疾病患病率研究 (ERb)；经颅磁异常促进反应的研究 帕金森病患者的刺激，识别与之相关的缺陷 钢琴家“过度使用”综合征，静脉注射丙种球蛋白的三项临床试验 神经肌肉疾病，双生子不和谐的随访研究 麻风性脊髓灰质炎和随后的脊髓灰质炎后综合征；临床试验 金刚烷胺治疗脊髓灰质炎后疲劳(MNB)；评价 偏侧帕金森病大鼠治疗后神经元萌发及行为恢复 羊膜细胞移植；会诊的验证研究 由美国药物信息中心提供；神经症的发病率研究 以色列的系统肿瘤；关岛运动神经元病的发病率研究 (Neb)；快速循环双相情感障碍的马尔可夫模型的发展， 强光照射与炎热关系的考察 绝经妇女的闪光(NIMH)：无症状中风危险因素的研究 以及它们对随后中风的存活率的影响，以及 中风后癫痫发作。

This project encompasses a wide scope of statistical collaboration and consultation with laboratories and branches within the Division of Intramural Research (DIR), and with other neuroscience units outside NIH. Particular consideration is given to statistical planning and design of experiments, statistical analysis of data, and statistical inference. Examples of current studies include: clinical trial of bioequivalence of alpha- mannose-terminated glucocerebrosidase from natural and recombinant source, clinical course and long-term outcome of patients treated with Ceredase/TM in Gaucher's disease, evaluation of skeletal responses of patients with Gaucher's disease treated with Ceredase/TM ,longitudinal study of the clinical course of Fabry's disease (DMNB); clinical trials of felbamate for the treatment of intractable complex partial seizures, measurement of the effect of time from last seizure and seizure type on metabolic change as measured by PET, study of epilepsy progression to general tonic-clonic seizures (ERB); clinical trial of the effect of cyclosporine on lesion development in relapsing-remitting MS, modeling lesion recurrence in relapsing-remitting MS, clinical trial of DSG on lesion development in relapsing-remitting MS, monitoring MRI T2 weighted imaging in relapsing-remitting MS; determination of the role of B7:CD 28-CTLA-4 interaction in chronic relapsing EAE; examining the effect of accumulation of disease white matter in patients with relapsing-remitting MS (NIB); prevalence study of neurologic diseases in the Navajo tribe (ERB); study of abnormal facilitation response to transcranial magnetic stimulation in PD patients, identification of deficits associated with "over use" syndrome in pianists, three clinical trials of IV-IG in neuromuscular disorders, follow-up study of twins discordant for paralytic polio and subsequent post-polio syndrome; clinical trial of amantadine for the treatment of post-polio fatigue (MNB); evaluation of neuronal sprouting and behavioral recovery in hemiparkinsonian rats after amnion cell transplantation (SNB); validation study of consultations provided by U.S. drug information centers; incidence study of nervous system tumors in Israel; incidence study of motor neuron disease on Guam (NEB); development of Markov models for rapidly cycling bipolar disorder, examination of the relationship between bright light exposure and hot flashes in menopausal women (NIMH); studies of silent stroke risk factors and their implication for survival of a subsequent stroke, and risk of seizures following stroke.