STATISTICAL COORDINATING CENTER FOR COLLABORATIVE CLINICAL STUDIES

临床合作研究统计协调中心

• 批准号: 3760305
• 负责人: J H ELLENBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3760305
• 关键词: Parkinson's disease; South America; computer data analysis; cooperative study; data collection; family genetics; health science research support; health surveys; human data; mass screening; nervous system disorder epidemiology; patient /disease registry; statistical service /center; statistics /biometry; twin /multiplet

This project encompasses all statistical coordinating center responsibilities for collaborative clinical studies undertaken by this Section and the Office of the Chief. A major initiative involves the study of the etiology of Parkinson's disease (PD) using the twin pair registry of the National Academy of Sciences/National Research Council. The prevalent cases of PD in the more than 6,000 twin pairs in which both members are alive, will be identified. This observational study will establish: environmental, medical and family histories of both affected and unaffected members of the twin pairs; DNA banking; and measurement of progression of disease over time. This project will investigate genetic and environmental contributions and their interactions to the etiology of PD. A Cooperative Agreement has been funded for the clinical aspects of this study. BFSB is acting as the statistical coordinating center. The study is ongoing. A second collaborative project involves a two-phase prevalence survey of major neurologic disorders in Junin, a city of about 70,000 inhabitants, in the Province of Buenos Aires, Argentina. This household survey, funded by the Fundacion para la Investigacion en Neuroepidemiologia , is one of the largest of its kind in Latin America. On the basis of a two-stage systematic sample of households, 17,049 persons from 5,648 households were screened in phase 1, to identify those persons who possibly had a disorder of interest. In phase 2, the 817 persons screened as positive were evaluated (usually by means of a clinical examination) by neurologists using established diagnostic criteria. BFSB has collaborated on the design and data collection for this study, and is now collaborating on the data analysis and preparation of reports.

该项目包括所有统计协调中心 承担的合作临床研究的责任 科和科长办公室。 一项重大举措涉及 应用双生子研究帕金森病的病因 国家科学院/国家研究理事会注册处。 在6,000多对双胞胎中， 两名成员都还活着，将被确认身份。 这项观察性研究 将建立：环境，医疗和家族史， 双胞胎中受影响和未受影响的成员; DNA库;以及 测量疾病随时间的进展。该项目将 研究遗传和环境贡献及其 与PD病因的相互作用。 一项合作协议已 为这项研究的临床方面提供资金。 BFSB作为 统计协调中心。 这项研究正在进行中。 第二个合作项目涉及两个阶段的流行率调查， 朱宁是一个约有7万居民的城市， 位于阿根廷布宜诺斯艾利斯省。这项家庭调查， 由神经流行病学研究丰达西翁资助， 是拉丁美洲同类中最大的 根据两阶段 对5 648户家庭的17 049人进行了系统抽样 在第一阶段进行筛查，以确定那些可能患有 兴趣障碍。 在第二阶段，817人被筛选为阳性 通过以下方式进行评价（通常通过临床检查）： 神经科医生使用已建立的诊断标准。 BFSB有 合作设计和数据收集这项研究，是 目前正在合作进行数据分析和编写报告。