STATISTICAL COORDINATING CENTER FOR COLLABORATIVE CLINICAL STUDIES

该项目涵盖了所有统计协调中心 负责由该中心开展的协作临床研究 科室和科长办公室。一项重大倡议涉及 双生子对帕金森病的病因学研究 国家科学院/国家研究理事会登记处。 在6,000多对双胞胎中流行的帕金森病病例 两名成员都还活着，将被确认身份。这项观察性研究 将建立：两人的环境，医疗和家族史 双胞胎中受影响和未受影响的成员；DNA银行；以及 测量疾病随时间的进展情况。这个项目将 调查遗传和环境的贡献及其 相互作用对帕金森病的病因。一项合作协议已经达成 为这项研究的临床方面提供资金。BFSB是作为 统计协调中心。这项研究正在进行中。 第二个合作项目涉及两个阶段的患病率调查 朱宁是一座拥有约7万居民的城市，该市出现了严重的神经系统疾病， 在阿根廷布宜诺斯艾利斯省。这项家庭调查，资金 由Fundacion Parla Investigacion en NeuroEpidologia，是 这是拉丁美洲同类建筑中最大的。在两阶段的基础上 对5,648户家庭的17,049人进行了系统抽样 在第一阶段进行筛查，以确定哪些人可能患有 一种兴趣的混乱。在第二阶段，817人被筛查为阳性 评估(通常通过临床检查) 神经科医生使用既定的诊断标准。BFSB有 参与了这项研究的设计和数据收集， 目前在数据分析和报告编写方面进行合作。

This project encompasses all statistical coordinating center responsibilities for collaborative clinical studies undertaken by this Section and the Office of the Chief. A major initiative involves the study of the etiology of Parkinson's disease (PD) using the twin pair registry of the National Academy of Sciences/National Research Council. The prevalent cases of PD in the more than 6,000 twin pairs in which both members are alive, will be identified. This observational study will establish: environmental, medical and family histories of both affected and unaffected members of the twin pairs; DNA banking; and measurement of progression of disease over time. This project will investigate genetic and environmental contributions and their interactions to the etiology of PD. A Cooperative Agreement has been funded for the clinical aspects of this study. BFSB is acting as the statistical coordinating center. The study is ongoing. A second collaborative project involves a two-phase prevalence survey of major neurologic disorders in Junin, a city of about 70,000 inhabitants, in the Province of Buenos Aires, Argentina. This household survey, funded by the Fundacion para la Investigacion en Neuroepidemiologia , is one of the largest of its kind in Latin America. On the basis of a two-stage systematic sample of households, 17,049 persons from 5,648 households were screened in phase 1, to identify those persons who possibly had a disorder of interest. In phase 2, the 817 persons screened as positive were evaluated (usually by means of a clinical examination) by neurologists using established diagnostic criteria. BFSB has collaborated on the design and data collection for this study, and is now collaborating on the data analysis and preparation of reports.