MATERNAL INFECTION STUDY

围产期合作项目(CPP)数据分析 在产妇感染方面仍在继续。(CPP是一项 对大约60,000名孕妇和随访的前瞻性研究- 把他们的孩子抚养到七岁。)二 使用了主要的方法，一个前瞻性的和一个案例的 控制进场。因为所有的血清学确认都是 怀孕期间所有妇女都会受到常见的感染 项目是不可行的，病例对照设计 已经实施了11种抗原滴度的评估 异常儿童与匹配的对照组妇女相比 正常的孩子。这项研究没有显示出任何明确的关联 在妊娠中期和晚期之间的感染之间 怀孕和对孩子的特定伤害。一项前瞻性研究 儿童发病率与母体抗体的关系 孕妇人群中弓形虫病的水平一直是 完成。弓形虫病的前瞻性血清学研究， 根据研究中的前23,000例怀孕情况， 耳聋、小头畸形和低智商的风险增加 母亲抗体水平高的妇女所生的孩子 弓形虫病。报道调查结果的手稿 弓形虫病研究已被接受出版， 血清学确诊感染的研究已提交给 出版。

Analysis of the Collaborative Perinatal Project (CPP) data continues in the area of maternal infection. (The CPP is a prospective study of approximately 60,000 gravidae and the follow- up of their children through the seventh year of life.) Two primary methodologies have been used, a prospective and a case control approach. Since serological confirmation of all of the common infections occurring during pregnancy on all women in the project would not have been feasible, a case control design has been implemented assessing the titer of 11 antigens in women with abnormal children, in comparison with matched control women with normal children. This study did not show any clear association between infection during the second and third trimester of pregnancy and specific damage to the child. A prospective study of the association of childhood morbidity with maternal antibody level to toxoplasmosis in a population of pregnant women has been completed. The prospective serological study of toxo-plasmosis, based on the first 23,000 pregnancies in the study, has shown increases in the risk of deafness, microcephaly, and low IQ among children born to women with high maternal antibody to toxoplasmosis. The manuscript reporting the results of the toxoplasmosis study has been accepted for publication, and the study of serologically confirmed infections has been submitted for publication.