MATERNAL INFECTION STUDY

对合作围产期项目(CPP)数据的分析仍在继续 母体感染的地区。(CPP是一项前瞻性研究 大约60,000名孕妇及其子女通过 生命的第七年。)围产期母体感染的关系 正在使用两种方法检查怀孕和孩子较晚的状态 母亲的临床和血清学确诊感染。 使用了两种主要的方法，前瞻性对照和病例对照 接近。特定儿童结局风险的前瞻性评估 用于所有临床确诊的感染。因为血清学 确认在怀孕期间发生的所有常见感染 该项目中的所有女性都不是可行的，病例对照 已经实施了评估女性11种抗原效价的设计 与患有异常儿童的对照组妇女相比， 正常的孩子。对特定感染的特别研究，如 尖锐湿疣和弓形虫病正在进行或已经完成， 流行性出血热病毒滴度和频率分布的描述性研究 不同种族和年龄孕妇对不同抗原的血清转化率 孕妇人口调查工作已经完成。未来者 弓形虫病的血清学研究及其与妊娠的关系 根据研究中的前23,000例怀孕，结果显示 儿童患耳聋、小头畸形和低智商的风险增加 母亲对弓形虫抗体高的妇女所生。

Analysis of the Collaborative Perinatal Project (CPP) data continues in the area of maternal infection. (The CPP is a prospective study of approximately 60,000 gravidae and the follow-up of their children through the seventh year of life.) The relationship of maternal infection during pregnancy with the later status of the child is being examined using both clinical and serologically-confirmed infections in the mother. Two primary methodologies have been used, a prospective and a case control approach. A prospective assessment of risk of specified childhood outcome was used for all clinically confirmed infections. Since serological confirmation of all of the common infections occurring during pregnancy on all women in the project would not have been feasible, a case control design has been implemented assessing the titer of 11 antigens in women with abnormal children, in comparison with matched control women with normal children. Special studies of specific infections such as condylomata and toxoplasmosis are in progress or have been completed and a descriptive study of the distribution of titers and frequency of seroconversions by race and age of gravidae for various antigens in a population of pregnant women has been completed. The prospective serological study of toxoplasmosis and its relationship with pregnancy outcome, based on the first 23,000 pregnancies in the study, has shown increases in the risk of deafness, microcephaly and low IQ among children born to women with high maternal antibody to toxoplasmosis.