EEG LEARNING CORRELATES USING SCALP AND INTRACRANIAL DEPTH ELECTRODES

使用头皮和颅内深度电极进行脑电图学习关联

• 批准号: 3922455
• 负责人: R JOHNSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3922455
• 关键词: attention; auditory stimulus; behavior disorders; cerebral dominance; direct cortical response; electrodes; electroencephalography; evoked potentials; hippocampus; human subject; learning; memory; mental disorder diagnosis; mental disorders; mood disorders; neural information processing; neuropsychology; perception; psychobiology; psychosurgery; visual stimulus

Information processing was monitored by averaged evoked response techniques The electroencephalographic (EEG) activity was recorded from left and right brain regions during memory and perception in normal subjects, patients with unilateral temporal lobectomy, and patients with neuropsychiatric disorders. EEG disturbances in brain-behavior relations in psychiatric patients were also evaluated, relating left and right brain dysfunctioning to activity to maladaptive ideative and emotional reactions, respectively. In temporal lobectomy patients, P300 amplitude was found to be inversely proportional to stimulus probability in the same way as for normal controls, and P300 amplitude was directly related to task difficulty. A double dissociation was found in the patients' responses to auditory and visual material. That is, for auditory material, left temporal patients showed smaller P300s over frontal scalp compared to right temporal patients and normal individuals, whereas, for visual material, right temporal patients manifested smaller P300s over frontal scalp compared to left temporal patients and or normal individuals. However, there were no consistent hemispheric asymmetries which distinguished the left from the right temporal patients, or either group from normal subjects. These data discount the hypothesis that medial temporal structures, including the hippocampus, serve as a sole generator of P300. More specifically the data indicate that processing of auditory and visual stimuli is dependent to some extent on the character of the material and the integrity of left and right brain mechanisms.

用平均诱发反应监测信息加工 技术记录脑电活动 在记忆和感知过程中， 正常受试者，单侧颞叶切除术患者，以及 神经精神疾病患者。 脑电图紊乱 精神病患者的脑行为关系也 评估，将左右脑功能障碍与活动联系起来 适应不良的意念和情绪反应。 在颞叶切除术患者中，P300振幅被发现是 与刺激概率成反比， P300波幅与正常对照组有直接相关性， 任务难度。 在患者的认知功能中存在双重分离， 对听觉和视觉材料的反应 也就是说，对于听觉 材料，左颞叶患者表现出较小的P300比额 与右颞患者和正常个体相比， 而对于视觉材料，右颞叶患者表现为 与左颞叶患者相比，额部头皮上的P300更小 或者正常的个体。 然而，没有一致的 左右半球的不对称性 颞叶患者或正常受试者的任一组。 这些 数据不支持内侧颞叶结构的假设， 包括海马体，作为P300的唯一发生器。 更 具体地说，数据表明，听觉和 视觉刺激在某种程度上取决于 左右脑机制的完整性。