EEG LEARNING CORRELATES USING SCALP AND INTRACRANIAL DEPTH ELECTRODES

使用头皮和颅内深度电极进行脑电图学习关联

• 批准号: 4696781
• 负责人: R JOHNSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696781
• 关键词: Alzheimer's disease; behavior disorders; cerebral dominance; electrodes; electroencephalography; evoked potentials; human subject; interview; learning; memory; mental disorder diagnosis; mental disorders; neural information processing; neuropsychology; perception; psychophysiology; psychosurgery

Information processing was monitored and quantified by averaged evoked response techniques. The elecrographic activity was recorded from left and right brain regions during memory and perception in normal subjects, patients with unilateral temporal lobectomy, and patients with neuropsychiatric disorders. Electroencephalographic disturbances in brain-behavior relations in psychiatric patients were also evaluated, relating left brain dysfunction to ideational disorders, and right brain activity to maladaptive emotional reactions. In temporal lobectomy patients, P300 amplitude was found to be inversely proportional to stimulus probability in the same way as for normal controls, and larger P300s were elicited in reaction time. For visual material, right temporal patients manifested smaller P300s at frontal sites than either left temporal or normal individuals. Moreover, there were no consisent hemispheric asymmetries which distinguished the left or right temporal patients, or either group from normal subjects. These data discount the hypothesis that medial temporal structures, including the hippocampus, serve as a sole generator of P300. More specifically the data indicate that processing of auditory and visual stimuli is dependent to a great extent on the character of the material and the integrity of left and right brain mechanisms.

信息处理被监测和量化的平均诱发电位 响应技术。 从左至右记录心电图活动， 在正常受试者的记忆和感知过程中的右脑区域， 单侧颞叶切除术患者， 神经精神障碍 脑电图紊乱 还评估了精神病患者的脑行为关系， 将左脑功能障碍与概念障碍联系起来， 适应不良的情绪反应。 在颞叶切除术患者中，P300振幅被发现成反比， 与刺激概率成正比，与正常情况下的方式相同 在反应时中诱发较大的P300。 For visual 材料，右颞叶患者表现出较小的P300在额叶网站 比左颞叶或正常人都要多 此外，没有 左右半球的不对称性 颞叶患者或正常受试者的任一组。 这些数据 不考虑内侧颞叶结构，包括 海马是P300唯一发生器。 更具体地说， 表明听觉和视觉刺激处理依赖于 在很大程度上的性质的材料和完整性的左， 右脑机制