EVENT-RELATED POTENTIAL STUDIES OF NORMAL AND ABNORMAL COGNITIVE PROCESSING

正常和异常认知处理的事件相关潜力研究

• 批准号: 3881820
• 负责人: R JOHNSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3881820
• 关键词: AIDS dementia complex; Alzheimer's disease; HIV infections; Turner's syndrome; attention; brain electrical activity; cerebral palsy; cognition; cognition disorders; dementia; disease /disorder model; electrical potential; electrostimulus; human subject; language; mathematical ability; memory; memory disorders; mental process; neural information processing; neuropsychological tests; psychosurgery; slow potential; stimulus /response

Event-related brain potentials (ERP) were used to study cognitive processes such as short- and long-term memory, spatial attention and visual search, mental rotation, mental arithmetic, and language comprehension. ERP studies of normal subjects were intended to reveal the brain mechanisms underlying cognition. Studies of patients with neuropsychiatric disorders were intended to provide information on the physiological sources of these cognitive processes while allowing us to characterize better the patients' information processing deficits. Data analysis continues on studies of temporal lobectomy patients, Turner's patients, and the maturation of cognitive processes. ERP studies of dementia are continuing for patients with Alzheimer's disease while data collection has been completed for patients with HlV disease and progressive supranuclear palsy. The results from the HIV and PSP studies indicate that, in the earliest stages of subcortical disease, processing at the cortical level is more affected than processing at the subcortical level (i.e., resembling a cortical dementia). This pattern reverses as the subcortical disease progresses. Studies of the mechanisms underlying and affecting attentional processes continue. Data collection was completed recently in two studies, one on how normal controls visually search a spatial array for items previously stored in short-term memory and one on the effects of on attention in patients with chronic fatigue syndrome and normal controls. Studies with Daniel Ruchkin have been aimed at understanding a newly emerging class of ERP components known as slow waves. Completed studies have investigated the processes of mental arithmetic, mental rotation, and short-term memory. Data collection is nearly complete in an experiment on the differences between rehearsal processes for verbal and spatial material. Studies with Wolfgang Miltner have been aimed at providing additional data on the neural sources of ERP components. Completed studies have provided a comparison of the ERP components elicited by auditory and somatosensory stimuli using large electrode montages. A new experiment was recently finished so that the neural source localization program, BESA, can be applied to the data. Patient and control data have been used to validate the predictions of Johnson's model of the variables controlling P300 amplitude. These data revealed that, contrary to the widely accepted notion, the P300 is a modality-dependent component whose amplitude represents the sum of a number of distinct neural generators which we are attempting to characterize and localize.

事件相关脑电位(ERP)用于研究认知过程 例如短期和长期记忆、空间注意和视觉搜索， 心理旋转、心算和语言理解。企业资源计划研究 旨在揭示正常受试者大脑机制 认知力。对神经精神障碍患者的研究是 旨在提供有关这些疾病的生理来源的信息 认知过程，同时使我们能够更好地描述患者的 信息处理缺陷。继续进行数据分析的研究 颞叶切除术患者、Turner‘s患者和成熟度 认知过程。痴呆症的事件相关电位研究仍在继续 患有阿尔茨海默氏症，而数据收集已经完成 HLV病和进行性核上性麻痹患者。结果是 来自艾滋病毒和PSP的研究表明，在艾滋病的早期阶段 皮质下疾病，皮层水平的处理比 在皮质下水平的处理(即，类似于皮质痴呆)。 这种模式随着皮质下疾病的进展而逆转。对中国传统文化的研究 注意过程的基础和影响机制仍在继续。数据 最近完成了两项研究，其中一项是关于正常程度 控件在空间数组中可视化地搜索以前存储在 短时记忆及其对注意功能的影响 慢性疲劳综合征和正常对照组。丹尼尔·鲁奇金的研究 旨在了解一类新出现的ERP组件 被称为慢波。已完成的研究已经调查了 心算、心理旋转和短期记忆。数据收集 即将完成一项关于排练和排练之间的差异的实验 语言和空间材料的加工过程。与沃尔夫冈·米尔特纳的研究 旨在提供更多关于事件相关电位神经来源的数据 组件。已完成的研究提供了与企业资源规划的比较 由听觉和躯体感觉刺激引起的成分 电极蒙太奇最近完成了一项新的实验，使 神经源定位程序BESA可以应用于这些数据。 患者和对照数据已经被用来验证预测 Johnson提出的控制P300波幅的变量模型。这些数据 与被广泛接受的概念相反，P300是一款 与模式相关的分量，其幅度表示一个数字的和 我们试图描述的不同的神经生成器的特征 本地化。