EEG LEARNING CORRELATES USING SCALP AND INTRACRANIAL DEPTH ELECTRODES

使用头皮和颅内深度电极进行脑电图学习关联

• 批准号: 3968883
• 负责人: R JOHNSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968883
• 关键词: Alzheimer's disease; attention; auditory stimulus; behavior disorders; cerebral dominance; electrodes; electroencephalography; evoked potentials; hippocampus; human subject; interview; learning; memory; mental disorder diagnosis; mental disorders; neural information processing; neuropsychology; perception; psychobiology; psychosurgery; visual stimulus

Information processing was monitored by averaged evoked response techniques. The electrographic activity was recorded from left and right brain regions during memory and perception in normal subjects, patients with unilateral temporal lobectomy, and patients with neuropsychiatric disorders. Electroencephalographic disturbances in brain-behavior relations in psychiatric patients were also evaluated, relating left and right brain dysfunctioning to activity to maladaptive ideative and emotional reactions, respectively. In temporal lobectomy patients, P300 amplitude was found to be inversely proportional to stimulus probability in the same way as for normal controls, and larger P300s were elicited in reaction time. For visual material, right-temporal patients manifested smaller P300s at frontal sites than either left-temporal or normal individuals. Moreover, there were no consistent hemispheric asymmetries which distinguished the left- or right-temporal patients, or either group from normal subjects. These data discount the hypothesis that medial temporal structures, including the hippocampus, serve as a sole generator of P300. More specifically the data indicate that processing of auditory and visual stimuli is dependent to a great extent on the character of the material and the integrity of left and right brain mechanisms.

用平均诱发反应监测信息加工 技术. 从左和右记录电图活动 正常人、病人和老年人在记忆和知觉过程中的脑区 单侧颞叶切除术，以及神经精神病患者 紊乱 脑行为的脑电图紊乱 精神病患者的关系也进行了评估，有关左， 右脑功能失调，活动适应不良的想法， 情绪反应，分别。 在颞叶切除术患者中，P300振幅被发现成反比， 与刺激概率成正比，与正常情况下的方式相同 在反应时中诱发较大的P300。 For visual 材料，右颞患者表现出较小的P300在额叶网站 比左颞叶或正常人都要多 此外，没有 一致的半球不对称性，区分了左， 右颞患者，或正常受试者的任何一组。 这些数据 不考虑内侧颞叶结构，包括 海马是P300唯一发生器。 更具体地说， 表明听觉和视觉刺激处理依赖于 在很大程度上的性质的材料和完整性的左， 右脑机制