DEVELOPMENT OF BIOCALORIMETERS FOR SOLUTION AND CELL BIOCHEMICAL STUDIES

一种新型全钽止流装置的研制 微量热计已经发展到了一套完整的 测试数据已经运行，仪器现已投入使用。 一些DNA药物结合的实验正在进行中 反应。这项工作是与科学家合作完成的 在罗格斯大学。每种试剂只有80微升 每种反应都需要。它的灵敏度是它的十倍 每种试剂需要1毫升的间歇量热计。对于反应 在半衰期快于0.1秒的情况下，一次反应可以每3秒进行一次 几分钟。仪器由微型计算机控制，该微型计算机 获取数据并在线分析。广泛的工作与 血红蛋白计划在来年与 NIA、LAIR和约翰·霍普金斯大学的科学家们。

The development of a new all tantalum stopped flow microcalorimeter has proceeded to the point that a complete set of test data have been run the instrument is now operational. Experiments are in progress on a number of DNA drug binding reactions. This wok is being done in collaboration with scientists at Rutgers University. Only 80 microliters of each reagent are needed per reaction. The sensitivity is ten times that of the batch calorimeter requiring 1 ml of each reagent. For reactions with halflives faster than 0.1 second, a reaction can run every 3 minutes. The instrument is controlled by a microcomputer which takes the data and analyzes it on line. Extensive work with hemoglobin is planned for the coming year in collaboration with scientists at NIA, LAIR and Johns Hopkins University.