EFFECT OF AGE ON HEMODYNAMIC AND METABOLIC EXERCISE PERFORMANCE

年龄对血流动力学和代谢运动表现的影响

• 批准号: 4687929
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687929
• 关键词: aging; cardiovascular stress test; catecholamines; heart rate; hemodynamics; male; metabolism

Maximal treadmill exercise with measurement of expired gases has been performed in more than 600 clinically normal BLSA volunteers over the past 5 years. Although a formal data analysis is currently in progress, it appears that the strong age-related decline in both maximal heart rate and maximal aerobic capacity (VO2max) noted in small BLSA examples will be confirmed. To determine the role of catecholamines in the well known age-related decline in exercise capacity, we measured plasma norepinephrine (NE) and epinephrine (E) at rest and during maximal treadmill exercise in 24 healthy men. Resting NE was not age-related but resting E was higher in men 68-77 years old than in those 22-37 or 44-55 years of age. At maximal effort both NE and E were higher in the elderly men. Furthermore, at submaximal workloads NE and E increased with age, both before and after normalization as a percent of peak VO2. In another study, the metabolic effect of relatively prolonged aerobic exercise, is being assessed in healthy men.

最大跑步机运动与呼出气体的测量已被 过去在600多名临床正常的BLSA志愿者中进行 5年 虽然目前正在进行正式的数据分析， 似乎最大心率和心率的年龄相关性下降， 在小型BLSA示例中记录的最大有氧能力（VO 2 max）将是 确认 为了确定儿茶酚胺在众所周知的年龄相关的 运动能力下降，我们测量了血浆去甲肾上腺素（NE）和 24名健康人在安静和最大跑步机运动期间的肾上腺素（E） 男人 静息NE与年龄无关，但静息E在68-77岁男性中较高 22-37岁或44-55岁的人。 尽最大努力 老年男性NE和E均较高。 此外，在次最大 工作负荷NE和E在正常化前后均随年龄增长而增加 占峰值VO 2的百分比。 在另一项研究中， 在健康男性中进行评估。