EVALUATION OF PERIPHERAL BLOOD FLOW IN NORMAL MAN BY PLETHYSMOGRAPHY

体积描记法评价正常人外周血流

• 批准号: 3821411
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821411
• 关键词: aging; cardiovascular pharmacology; health surveys; human middle age (35-64); human old age (65+); human subject; isoproterenol; longitudinal human study; nitroferricyanide; peripheral blood vessel; peripheral blood vessel disorder; plethysmography; rest; vein occlusion; young adult human (21-34)

Although the incidence of degenerative changes in the blood vessels is well known to increase with advancing age, quantitative data on the changes in peripheral blood flow due to the aging process per se are lacking. Venous occlusion plethysmography has been shown to be the most accurate and reproducible method to measure peripheral arterial flow. We have used this method to evaluate peripheral blood flow in healthy subjects aged 20-83 years from the Baltimore Longitudinal Study of Aging (BLSA) both at rest and in response to post-occlusion hyperemia, which results in near-maximal flow. Neither resting nor post-occlusion hyperemic blood flow were related to age in these 146 BLSA men and women who underwent occlusions of 1, 2, and 3 minutes both at 26 degrees C and 35 degrees C. These results suggest that peripheral arterial flow is not limited by age per se in man. In a second protocol, the response of peripheral blood flow to intravenous infusion of isoproterenol and sodium nitroprusside was determined by plethysmography in 25 healthy volunteers ages 25- 84 years. The results of this study are pending.

尽管血液中退行性变化的发生率 众所周知，血管随着年龄的增长而增加，数量 老年人外周血流量变化的数据 过程本身是缺乏的。静脉闭塞体积描记术有 已被证明是最准确和可重复性最好的方法 测量外周动脉血流量。我们已经使用这种方法来 20-83岁健康受试者外周血流量的评估 巴尔的摩老龄化纵向研究(BLSA)的两年 在休息时和对闭塞后充血的反应，这导致 在接近最大流量时。既不休息也不咬合后 146名BLSA男性的充血血流与年龄有关 同时闭塞1分钟、2分钟和3分钟的女性 在26摄氏度和35摄氏度这些结果表明 男性的外周动脉血流不受年龄本身的限制。 在第二种方案中，外周血流量对 静脉输注异丙肾上腺素和硝普钠。 25名25岁健康志愿者的体积描记测定 84岁了。这项研究的结果尚待公布。