EVALUATION OF PERIPHERAL BLOOD FLOW IN NORMAL MAN BY PLETHYSMOGRAPHY

体积描记法评价正常人外周血流

• 批准号: 3823132
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823132
• 关键词: aging; cardiovascular pharmacology; environmental stressor; health surveys; hot climate; human middle age (35-64); human old age (65+); isoproterenol; longitudinal human study; nitroferricyanide; peripheral blood vessel; peripheral blood vessel disorder; plethysmography; rest; stress; vein occlusion; young adult human (21-34)

Although the incidence of degenerative changes in the blood vessels is well known to increase with advancing age, quantitative data on the changes in peripheral blood flow due to the aging process per se are lacking. Venous occlusion plethysmography had been shown to be the most accurate and reproducible method to measure peripheral arterial flow. We have used this method to evaluate peripheral blood flow in healthy subjects aged 20-83 years from the Baltimore Longitudinal Study of Aging (BLSA) both at rest and in response to post-occlusion hyperemia, which results in near-maximal flow. Neither resting nor post-occlusion hyperemic blood flow were related to age in these 146 BLSA men and women who underwent occlusions of 1,2, and 3 minutes both at 26 degrees C and 35 degrees C. These results suggest that peripheral arterial flow is not limited by age per se in man. In a second protocol, the response of peripheral blood flow to interavenvous infusion of isoproterenol and sodium nitroprusside was determined by plethysmography in 25 healthy volunteers ages 25-84 years. The results of this study are pending.

尽管血管退行性改变的发生率很高 已知随着年龄的增长而增加，关于 衰老过程本身导致的外周血流量不足。静脉 咬合体积描记术已被证明是最准确和 测量外周动脉血流的可重复性方法。我们用过这个 20~83岁健康人外周血流量的测定方法 巴尔的摩老龄化纵向研究(BLSA)的几年 以及对闭塞后充血的反应，这导致近乎最大 流。静息和闭塞后的充血血流量都没有关系 对这146名BLSA男性和女性进行了1，2，和 在26摄氏度和35摄氏度下均为3分钟。这些结果表明 男性的外周动脉血流不受年龄本身的限制。 在第二种方案中，外周血流量对 静脉输注异丙肾上腺素和硝普钠。 对25名年龄在25-84岁的健康志愿者进行了体积描记。 这项研究的结果尚待公布。