EFFECT OF AGE ON HEMODYNAMIC AND METABOLIC EXERCISE PERFORMANCE IN NORMAL MAN

年龄对正常人血流动力学和代谢运动表现的影响

• 批准号: 3821453
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821453
• 关键词: aging; blood lipid; blood pressure; cardiovascular stress test; catecholamines; epinephrine; exercise; heart metabolism; heart rate; hemodynamics; human middle age (35-64); human old age (65+); metabolism; muscle metabolism; norepinephrine; respiratory gas level; rest; statistics /biometry; young adult human (21-34)

Maximal treadmill exercise with measurement of expired gases has been performed in, more than 600 clinically normal BLSA volunteers over the past 5 years. Although a formal data analysis is currently in progress, it appears that the strong age-related decline in both maximal heart rate and maximal aerobic capacity (VO2max) noted in small BLSA samples will be confirmed. However, age-related changes in V02max are attenuated markedly when V02max is normalized for muscle mass. To determine the role of catecholamines in the well known age- related decline in exercise capacity, we measured plasma norepinephrine (NE) and epinephrine (E) at rest and during maximal treadmill exercise in 24 healthy men. Resting NE was not age-related but resting E was higher in men 68-77 years old than in those 22-37 or 44-55 years of age. At maximal effort both NE and E were higher in the elderly men. Furthermore, at submaximal workloads NE and E increased with age, both before and after normalization for relative effort as a percent of peak V02. In another study, the metabolic effect of relatively prolonged aerobic exercise, is being assessed in healthy men. The relationship of VO2max to blood lipid levels and blood pressure is being determined in the entire active BLSA population via a multivariate analysis done in collaboration with the Metabolism Section, LCP.

最大跑步机运动并测量呼出气体 已经在超过600例临床正常的BLSA中进行了 志愿者在过去的五年里 虽然正式的数据分析 目前正在进行中，似乎与年龄有关的强烈 最大心率和最大有氧能力下降 将确认小BLSA样本中记录的最大摄氧量。 然而，V02 max的年龄相关变化显著减弱， 当VO 2 max针对肌肉质量标准化时。 为了确定儿茶酚胺在众所周知的年龄中的作用- 相关的运动能力下降，我们测量了血浆 去甲肾上腺素（NE）和肾上腺素（E）在休息和 24名健康男性进行最大负荷跑台运动。 静息NE为 与年龄无关，但68-77岁男性的静息E较高 而不是22-37岁或44-55岁的人。 尽最大努力， 老年男性NE、E增高。 此外，在 次最大负荷NE和E随年龄增加， 在相对努力归一化为峰值的百分比之后， V02. 在另一项研究中， 有氧运动，正在健康男性中进行评估。 最大摄氧量与血脂水平及血液流变学的关系 正在确定整个活动BLSA人群的压力 通过多变量分析， 代谢科，LCP。