EXERCISE-INDUCED ARRHYTHMIAS IN DIURETIC-TREATED SUBJECTS WITH HYPERTENSION

利尿剂治疗的高血压患者运动诱发的心律失常

• 批准号: 3821459
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821459
• 关键词: aging; antihypertensive agents; arrhythmia; cardiovascular disorder chemotherapy; cardiovascular pharmacology; cardiovascular stress test; diuretics; drug adverse effect; electrocardiography; exercise; human subject; hypertension; sudden cardiac death

Major controversy has recently arisen regarding a possible increased incidence of sudden cardiac death in hypertensive individuals treated with diuretics. To investigate a possible etiologic mechanism for such an outcome, we compared the prevalence and complexity of exercise-induced arrhythmias in BLSA subjects on chronic diuretic monotherapy for untreated hypertension with that in normotensive control group. Although the prevalence of exercise induced arrhythmias was higher in the diuretic treated group (D) that in controls (C) 57% versus 38%, p less than .05, this difference was due entirely to the higher prevalence of simple the groups was found in the prevalence of frequent or complex ectopic beats. Furthermore, within the D group, no difference in the occurrence of ectopic beats was found between men and women, those with resting ECG abnormalities and those without or between those with serum K less than 3.7 versus those with higher serum K.

最近出现了一个重大争议， 高血压患者心源性猝死发生率增加 用利尿剂治疗的人。 调查可能的 这种结果的病因机制，我们比较了 运动诱发心律失常的患病率和复杂性 接受慢性利尿剂单药治疗的BLSA受试者， 高血压组与血压正常对照组比较。 虽然 运动诱发心律失常的患病率在 利尿剂治疗组（D）为57%，对照组（C）为38%，p 小于0.05，这一差异完全是由于 简单组的患病率被发现， 频繁或复杂的异位搏动。 此外，在D 两组异位搏动发生率无差异 男性和女性之间，静息心电图异常者 血清K <3.7者或无血清K者 与血清钾水平高的人相比。