EXERCISE-INDUCED ARRHYTHMIAS IN DIURETIC-TREATED SUBJECTS WITH HYPERTENSION

最近出现了关于一种可能的 高血压病患者心脏性猝死发生率增加 接受利尿剂治疗的个人。调查一项可能的 这种结果的病因机制，我们比较了 运动性心律失常的患病率和复杂性 未经治疗的慢性利尿剂单一治疗的BLSA患者 高血压组与正常血压对照组。虽然 运动性心律失常的患病率在 利尿剂治疗组(D)与对照组(C)分别为57%和38%，P 低于0.05，这种差异完全是由于较高的 单纯性人群的患病率为 频繁或复杂的异位搏动。此外，在D内部， 组间异位搏动发生率无明显差异 在男性和女性之间，那些有静息心电图异常的人 血清K值在3.7以下者或无血钾者 与血钾水平较高的人相比

Major controversy has recently arisen regarding a possible increased incidence of sudden cardiac death in hypertensive individuals treated with diuretics. To investigate a possible etiologic mechanism for such an outcome, we compared the prevalence and complexity of exercise-induced arrhythmias in BLSA subjects on chronic diuretic monotherapy for untreated hypertension with that in normotensive control group. Although the prevalence of exercise induced arrhythmias was higher in the diuretic treated group (D) that in controls (C) 57% versus 38%, p less than .05, this difference was due entirely to the higher prevalence of simple the groups was found in the prevalence of frequent or complex ectopic beats. Furthermore, within the D group, no difference in the occurrence of ectopic beats was found between men and women, those with resting ECG abnormalities and those without or between those with serum K less than 3.7 versus those with higher serum K.