PROGNOSTIC SIGNIFICANCE OF SPECIFIC ELECTROCARDIOGRAPHIC FINDINGS

特定心电图结果的预后意义

• 批准号: 3823192
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823192
• 关键词: aging; angina pectoris; bradycardia; cardiovascular disorder epidemiology; cardiovascular stress test; congestive heart failure; electrocardiography; heart conduction system; heart disorder; heart rate; human middle age (35-64); human old age (65+); human subject; longitudinal human study; medical complication; prognosis; sudden cardiac death

We have previously characterized the long-term prognosis of 24 clinically healthy men with complete right bundle branch block (RBBB), identified from the BLSA population. Most recently we have characterized the clinical significance and prognosis of sinus bradycardia (SB) less than 50 beats/min in 47 healthy non-endurance trained men older than 40 years. When compared to a control group after a mean follow-up of 5.4 years, the SB group demonstrated a higher prevalence of associated conduction abnormalities (first degree AV block, left axis deviation and complete and incomplete RBBB) 43% versus 19%, p less than .05. On maximal treadmill exercise testing, maximal heart rate did not differ between groups, although exercise duration was greater in the SB group, 11.0 plus/minus 2.8 versus 9.7 plus/minus 3.1 min, p less than .05. None of the subjects with SB developed syncope, high degree AV block, or other manifestations of serious cardiac conduction disturbances during follow-up. Major cardiac events (angina pectoris, myocardial infarction, congestive heart failure or cardiac death) occurred in 8% of the SB group and 11% of controls over the 5.4 year mean observation period.

我们先前已经在临床上描述了24例患者的长期预后。 健康男性完全性右束支传导阻滞(RBBB)，由 BLSA的人口。 最近，我们描述了其临床意义和预后。 47例正常人窦性心动过缓(SB)<50次/分钟 非耐力训练的男性年龄超过40岁。当与控件进行比较时 经过平均5.4年的随访，SB组表现出 相关传导异常的患病率较高(一级房室 传导阻滞、心电轴左偏以及完全性和不完全RBBB)43%与 19%，p<0.05。关于最大跑台运动试验、最大心脏 尽管锻炼时间更长，但这一比率在不同组之间没有差异 在SB组，11.0加/减2.8对9.7加/减3.1分钟，p 而不是0.05。SB受试者无一例发生晕厥、高度房室传导阻滞 传导阻滞或严重心脏传导障碍的其他表现 在随访期间。主要心脏事件(心绞痛、心肌梗死 梗塞、充血性心力衰竭或心源性死亡)发生在 SB组和11%的对照组在5.4年的平均观察期内。