Mendelian randomization to hypothesis-free causal inference

孟德尔随机化到无假设因果推理

• 批准号: MC_UU_00011/1
• 负责人: George Davey Smith
• 金额: $ 364.93万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00011%2F1
• 关键词: Mendelian; randomization; hypothesis; free; causal

Obtaining reliable evidence on causes of disease and influences on disease progression is problematic, since many other factors than the ones under study may influence the outcomes. Using genetic variants that mimic potentially modifiable factors that may cause disease or influence its course has become a widely-used approach to improving such understanding. Known as “Mendelian randomization” the methodology is still under development. This programme of work will contribute to strengthening the reliability of the approach, and, in particular, investigate the application to identifying treatments for existing disease.

要获得关于疾病原因和对疾病进展的影响的可靠证据是有问题的，因为除了所研究的因素之外，还有许多其他因素可能会影响结果。使用基因变异来模仿可能导致疾病或影响其进程的潜在可修改因素，已成为提高这种理解的一种广泛使用的方法。这种被称为“孟德尔随机化”的方法仍在发展之中。这一工作方案将有助于加强这一方法的可靠性，特别是调查在确定现有疾病的治疗方法方面的应用。

项目成果

Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

教育、智力和阿尔茨海默病：来自多变量两样本孟德尔随机化研究的证据

• DOI: 10.1101/401042
• 发表时间: 2018
• 作者: Anderson E

Cancer prevention through weight control-where are we in 2020?

• DOI: 10.1038/s41416-020-01154-3
• 发表时间: 2021-03
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Anderson AS;Renehan AG;Saxton JM;Bell J;Cade J;Cross AJ;King A;Riboli E;Sniehotta F;Treweek S;Martin RM;UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)
• 通讯作者: UK NIHR Cancer and Nutrition Collaboration (Population Health Stream)

Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis.

• DOI: 10.1093/ije/dyaa183
• 发表时间: 2021-07-09
• 期刊: International journal of epidemiology
• 影响因子: 7.7
• 作者: Anderson EL;Richmond RC;Jones SE;Hemani G;Wade KH;Dashti HS;Lane JM;Wang H;Saxena R;Brumpton B;Korologou-Linden R;Nielsen JB;Åsvold BO;Abecasis G;Coulthard E;Kyle SD;Beaumont RN;Tyrrell J;Frayling TM;Munafò MR;Wood AR;Ben-Shlomo Y;Howe LD;Lawlor DA;Weedon MN;Davey Smith G
• 通讯作者: Davey Smith G

DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival.

• DOI: 10.1016/j.oraloncology.2018.08.021
• 发表时间: 2018-10
• 期刊: Oral oncology
• 影响因子: 4.8
• 作者: Ambatipudi S;Langdon R;Richmond RC;Suderman M;Koestler DC;Kelsey KT;Kazmi N;Penfold C;Ho KM;McArdle W;Ring SM;Pring M;Waterboer T;Pawlita M;Gaunt TR;Davey Smith G;Thomas S;Ness AR;Relton CL
• 通讯作者: Relton CL

Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.

• DOI: 10.1155/2018/2624981
• 发表时间: 2018
• 期刊: Journal of immunology research
• 影响因子: 4.1
• 作者: Ambatipudi S;Sharp GC;Clarke SLN;Plant D;Tobias JH;Evans DM;Barton A;Relton CL
• 通讯作者: Relton CL