Centre for Cognitive Ageing & Cognitive Epidemiology

认知老化中心

• 批准号: MR/K026992/1
• 负责人: Ian Deary
• 金额: $ 389.53万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK026992%2F1
• 关键词: Centre; Cognitive; Ageing; Epidemiology

In 2008 we formed the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) at the University of Edinburgh. This brought together a diverse range of scientists-epidemiologists, psychologists, geriatricians, clinical and basic neuroscientists, geneticists, statisticians, sociologists-to study how the brain and the body influence each other across the human life course and between generations. This application describes how CCACE enhanced this important research, and our plans for the next five years.The Centre brought a step change in our scientific achievements, our training of young scientists, and the communication of our research to wider, non-scientific groups. In science, we made achievements in four areas. (1) Our discoveries made us the leading international centre for the study of how intelligence from youth influences physical health, wellbeing, mental illness and mortality later in life (cognitive epidemiology). (2) In our large groups of older people on whom there were measures of intelligence from youth we made discoveries about genetic, lifestyle, brain structure and other contributions to the ageing of thinking (cognitive) skills that put us at the forefront internationally. Our discoveries on how diabetes affects thinking skills are based on one of the largest studies. (3) Our work uses theories of how the brain works to explore ageing effects on important specific thinking skills. This led to our devising tests for the early detection of dementia. (4) Our scientists working on the biological mechanisms of cognitive decline have made discoveries in human and animal studies that revealed likely biological routes for the amelioration of cognitive ageing. The Centre's presence brought new collaborators, gave us the capability to lead new cohorts and international consortia, and brought in a new Alzheimer Research Centre.The Centre brought a step change in the training of young scientists. The thriving mix of successful scientists working together has built up a community of PhD students concentrating on our aims. Many who are not funded by the Centre have come under our umbrella, adding value. We are meeting a need for the training of clinical scientists in our areas. The Centre has also been responsible for a step change in knowledge exchange. Our work with lay people, policy makers, artists, and business has brought our science out of the office and laboratory, creating awareness, new art, and products, and influencing policy.In the next five years the University of Edinburgh is generously supporting the Centre by funding a substantial amount of what originally came from LLHW funding. In research training, our vision is to mentor young scientists from the end of their PhDs and helpi them to develop into independent scientists in cognitive ageing and cognitive epidemiology to meet these important needs. In our four research Groups' fields we highlight the key areas in which we aim to make discoveries. Here, we mention a few. We are expanding our cognitive epidemiology work to examine how personality and thinking skills affect later health and illness. We shall conduct large-scale new genetic work in our cohorts of older people to find out how people's environments affect how their genes switch on and off and thereby affect thinking skills and other aspects of ageing. We shall conduct unusually large longitudinal studies to examine the parallel changes in brain scans and thinking skills, and the changes in cognition over 10 years in people with type 2 diabetes. We shall delve into specific thinking processes to find the precise sets of problems that best characterise various forms of normal and illness-based cognitive ageing. We shall undertake parallel human and animal work to investigate the importance and nature of changes in small blood vessels for brain health and thinking skills. We have an ambitious strategy for an expanded and more formalised programme of knowledge exchange.

2008年，我们在爱丁堡大学成立了认知老化和认知流行病学中心（CCACE）。这使得不同领域的科学家聚集在一起流行病学家、心理学家、老年病学家、临床和基础神经科学家、遗传学家、统计学家、社会学家来研究大脑和身体如何在人类生命过程中以及在两代人之间相互影响。本申请介绍了CCACE如何加强这项重要的研究，以及我们未来五年的计划。该中心在我们的科学成就，年轻科学家的培训以及我们的研究与更广泛的非科学团体的交流方面带来了一个飞跃。在科学方面，我们在四个方面取得了成就。(1)我们的发现使我们成为研究青年智力如何影响身体健康，幸福，精神疾病和死亡率的国际领先中心。(2)在我们的大型老年人群体中，我们对年轻人的智力进行了测量，我们发现了基因，生活方式，大脑结构和其他对思维（认知）技能老化的贡献，使我们处于国际前沿。我们关于糖尿病如何影响思维能力的发现是基于一项最大的研究。(3)我们的工作使用大脑如何工作的理论来探索衰老对重要的特定思维技能的影响。这促使我们设计了早期检测痴呆症的测试。(4)我们研究认知能力下降生物机制的科学家在人类和动物研究中取得了发现，揭示了改善认知能力老化的可能生物途径。该中心的存在带来了新的合作者，使我们有能力领导新的群体和国际财团，并带来了一个新的阿尔茨海默病研究中心，该中心在培训年轻科学家方面带来了一个重大变化。成功的科学家一起工作的蓬勃发展的组合已经建立了一个社区的博士生专注于我们的目标。许多没有得到该中心资助的人都加入了我们的保护伞，增加了价值。我们正在满足我们地区对临床科学家培训的需求。该中心还负责知识交流方面的一个步骤性变化。我们与外行人，政策制定者，艺术家和企业的合作使我们的科学走出了办公室和实验室，创造了意识，新的艺术和产品，并影响了政策。在未来五年内，爱丁堡大学通过资助最初来自LLHW资金的大量资金来慷慨支持该中心。在研究培训方面，我们的愿景是指导年轻科学家从博士毕业，并帮助他们发展成为认知老化和认知流行病学方面的独立科学家，以满足这些重要需求。在我们的四个研究小组的领域中，我们突出了我们旨在发现的关键领域。在这里，我们提到几个。我们正在扩大我们的认知流行病学工作，以研究个性和思维能力如何影响以后的健康和疾病。我们将在老年人群体中进行大规模的新基因研究，以了解人们的环境如何影响他们的基因开关，从而影响思维能力和衰老的其他方面。我们将进行不同寻常的大型纵向研究，以检查大脑扫描和思维技能的平行变化，以及2型糖尿病患者10年来认知的变化。我们将深入研究特定的思维过程，以找到最能解释各种形式的正常和基于疾病的认知老化的精确问题集。我们将进行平行的人类和动物工作，以调查小血管变化对大脑健康和思维能力的重要性和性质。我们有一个雄心勃勃的战略，扩大和更正式的知识交流计划。

项目成果

Stratifying depression by neuroticism: revisiting a diagnostic tradition using GWAS data

• DOI: 10.1101/547828
• 发表时间: 2019-02
• 期刊: bioRxiv
• 作者: M. Adams;David Mark Howard;M. Luciano;Toni‐Kim Clarke;G. Davies;W. Hill;Danny J. Smith;I. Deary;D. Porteous;A. McIntosh

Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition.

• DOI: 10.1017/s0033291719002629
• 发表时间: 2020-11
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Adams MJ;Howard DM;Luciano M;Clarke TK;Davies G;Hill WD;23andMe Research Team;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Smith D;Deary IJ;Porteous DJ;McIntosh AM
• 通讯作者: McIntosh AM

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

• DOI: 10.1038/nn.4398
• 发表时间: 2016-12
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Adams HH;Hibar DP;Chouraki V;Stein JL;Nyquist PA;Rentería ME;Trompet S;Arias-Vasquez A;Seshadri S;Desrivières S;Beecham AH;Jahanshad N;Wittfeld K;Van der Lee SJ;Abramovic L;Alhusaini S;Amin N;Andersson M;Arfanakis K;Aribisala BS;Armstrong NJ;Athanasiu L;Axelsson T;Beiser A;Bernard M;Bis JC;Blanken LM;Blanton SH;Bohlken MM;Boks MP;Bralten J;Brickman AM;Carmichael O;Chakravarty MM;Chauhan G;Chen Q;Ching CR;Cuellar-Partida G;Braber AD;Doan NT;Ehrlich S;Filippi I;Ge T;Giddaluru S;Goldman AL;Gottesman RF;Greven CU;Grimm O;Griswold ME;Guadalupe T;Hass J;Haukvik UK;Hilal S;Hofer E;Hoehn D;Holmes AJ;Hoogman M;Janowitz D;Jia T;Kasperaviciute D;Kim S;Klein M;Kraemer B;Lee PH;Liao J;Liewald DC;Lopez LM;Luciano M;Macare C;Marquand A;Matarin M;Mather KA;Mattheisen M;Mazoyer B;McKay DR;McWhirter R;Milaneschi Y;Mirza-Schreiber N;Muetzel RL;Maniega SM;Nho K;Nugent AC;Loohuis LM;Oosterlaan J;Papmeyer M;Pappa I;Pirpamer L;Pudas S;Pütz B;Rajan KB;Ramasamy A;Richards JS;Risacher SL;Roiz-Santiañez R;Rommelse N;Rose EJ;Royle NA;Rundek T;Sämann PG;Satizabal CL;Schmaal L;Schork AJ;Shen L;Shin J;Shumskaya E;Smith AV;Sprooten E;Strike LT;Teumer A;Thomson R;Tordesillas-Gutierrez D;Toro R;Trabzuni D;Vaidya D;Van der Grond J;Van der Meer D;Van Donkelaar MM;Van Eijk KR;Van Erp TG;Van Rooij D;Walton E;Westlye LT;Whelan CD;Windham BG;Winkler AM;Woldehawariat G;Wolf C;Wolfers T;Xu B;Yanek LR;Yang J;Zijdenbos A;Zwiers MP;Agartz I;Aggarwal NT;Almasy L;Ames D;Amouyel P;Andreassen OA;Arepalli S;Assareh AA;Barral S;Bastin ME;Becker DM;Becker JT;Bennett DA;Blangero J;van Bokhoven H;Boomsma DI;Brodaty H;Brouwer RM;Brunner HG;Buckner RL;Buitelaar JK;Bulayeva KB;Cahn W;Calhoun VD;Cannon DM;Cavalleri GL;Chen C;Cheng CY;Cichon S;Cookson MR;Corvin A;Crespo-Facorro B;Curran JE;Czisch M;Dale AM;Davies GE;De Geus EJ;De Jager PL;de Zubicaray GI;Delanty N;Depondt C;DeStefano AL;Dillman A;Djurovic S;Donohoe G;Drevets WC;Duggirala R;Dyer TD;Erk S;Espeseth T;Evans DA;Fedko IO;Fernández G;Ferrucci L;Fisher SE;Fleischman DA;Ford I;Foroud TM;Fox PT;Francks C;Fukunaga M;Gibbs JR;Glahn DC;Gollub RL;Göring HH;Grabe HJ;Green RC;Gruber O;Gudnason V;Guelfi S;Hansell NK;Hardy J;Hartman CA;Hashimoto R;Hegenscheid K;Heinz A;Le Hellard S;Hernandez DG;Heslenfeld DJ;Ho BC;Hoekstra PJ;Hoffmann W;Hofman A;Holsboer F;Homuth G;Hosten N;Hottenga JJ;Hulshoff Pol HE;Ikeda M;Ikram MK;Jack CR Jr;Jenkinson M;Johnson R;Jönsson EG;Jukema JW;Kahn RS;Kanai R;Kloszewska I;Knopman DS;Kochunov P;Kwok JB;Lawrie SM;Lemaître H;Liu X;Longo DL;Longstreth WT Jr;Lopez OL;Lovestone S;Martinez O;Martinot JL;Mattay VS;McDonald C;McIntosh AM;McMahon KL;McMahon FJ;Mecocci P;Melle I;Meyer-Lindenberg A;Mohnke S;Montgomery GW;Morris DW;Mosley TH;Mühleisen TW;Müller-Myhsok B;Nalls MA;Nauck M;Nichols TE;Niessen WJ;Nöthen MM;Nyberg L;Ohi K;Olvera RL;Ophoff RA;Pandolfo M;Paus T;Pausova Z;Penninx BW;Pike GB;Potkin SG;Psaty BM;Reppermund S;Rietschel M;Roffman JL;Romanczuk-Seiferth N;Rotter JI;Ryten M;Sacco RL;Sachdev PS;Saykin AJ;Schmidt R;Schofield PR;Sigurdsson S;Simmons A;Singleton A;Sisodiya SM;Smith C;Smoller JW;Soininen H;Srikanth V;Steen VM;Stott DJ;Sussmann JE;Thalamuthu A;Tiemeier H;Toga AW;Traynor BJ;Troncoso J;Turner JA;Tzourio C;Uitterlinden AG;Hernández MC;Van der Brug M;Van der Lugt A;Van der Wee NJ;Van Duijn CM;Van Haren NE;Van T Ent D;Van Tol MJ;Vardarajan BN;Veltman DJ;Vernooij MW;Völzke H;Walter H;Wardlaw JM;Wassink TH;Weale ME;Weinberger DR;Weiner MW;Wen W;Westman E;White T;Wong TY;Wright CB;Zielke HR;Zonderman AB;Deary IJ;DeCarli C;Schmidt H;Martin NG;De Craen AJ;Wright MJ;Launer LJ;Schumann G;Fornage M;Franke B;Debette S;Medland SE;Ikram MA;Thompson PM
• 通讯作者: Thompson PM