Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

1936 年洛锡安出生队列中的脑成像和认知衰老：III

• 批准号: MR/M013111/1
• 负责人: Ian Deary
• 金额: $ 134.09万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM013111%2F1
• 关键词: Brain; imaging; cognitive; ageing; Lothian

As human populations age across the planet, increasingly significant resources will be needed to manage and care for some older people. Cognitive ageing, the process by which some cognitive abilities decline in older age, is of particular concern, leading as it does to reduced quality of life, loss of independence, and, in its later stages, increased risk of dementia. Characterising the biological causes of cognitive ageing is therefore important if we are to reduce the burden of ageing at both the individual and societal level.In this proposal we request funds to collect and analyze brain magnetic resonance imaging (MRI) and carotid artery Doppler ultrasound data from participants of the Lothian Birth Cohort 1936. They are a large group of relatively healthy community-dwelling subjects in their late seventies. This cohort is unique in having cognitive data from youth (a well-validated measure of IQ obtained at age 11 years), and repeat cognitive testing, brain imaging, genetic, epigenetic, lifestyle, psychological, social and other important information obtained from ages 70, 73, 76 years, and to be collected at age 79.By undertaking a third wave of brain MRI and carotid ultrasound scanning, we will have detailed imaging data spanning most of the eighth decade of life (73 to 79 years) during which risk of dementia increases. Longitudinal imaging data obtained at three time points in older age is rare and will allow a thorough exploration of changes in brain structure with age (e.g. loss of brain grey and white matter), how these changes relate to cognitive ability measured across the whole life course, and what factors (e.g. genetics, diet, exercise, etc.) are most responsible for these changes. Understanding these relationships is an important step in helping to develop strategies to slow age-related cognitive decline, and in characterising what role cognitive ageing plays in heralding dementia.The present application is for minority funding for a project that also has funding from Age UK for the collection of the cognitive, medical, biomarker, and psychosocial data and their collation and analyses.

随着全球人口老龄化，管理和照顾一些老年人将需要越来越多的资源。认知老化是一些认知能力在老年时下降的过程，尤其令人担忧，它会导致生活质量下降，丧失独立性，并在后期增加患痴呆症的风险。因此，如果我们要在个人和社会层面上减少老龄化的负担，确定认知老化的生物学原因是重要的。在这项提案中，我们要求资金收集和分析1936年洛锡安出生队列的参与者的脑磁共振成像(MRI)和颈动脉多普勒超声数据。他们是一大群相对健康的社区居民，年近七旬。这个队列的独特之处在于拥有来自年轻人的认知数据(这是一种在11岁时获得的经过良好验证的智商衡量标准)，以及重复认知测试、大脑成像、遗传、表观遗传学、生活方式、心理、社会和其他重要信息，这些信息是从70岁、73岁、76岁获得的，并将在79岁时收集。通过进行第三波脑部核磁共振和颈动脉超声扫描，我们将获得跨越80年(73至79岁)痴呆症风险增加的大部分时间的详细成像数据。在老年人的三个时间点获得的纵向成像数据很少见，可以彻底探索大脑结构随年龄的变化(例如大脑灰质和白质的丧失)、这些变化与整个生命过程中测量的认知能力的关系，以及哪些因素(例如遗传、饮食、锻炼等)。对这些变化负有最大责任。了解这些关系是帮助制定减缓与年龄相关的认知衰退的策略的重要一步，也是描述认知老化在预测痴呆方面所扮演的角色的重要一步。目前的申请是为一个项目提供少数人资助，该项目也得到了英国Age UK的资助，用于收集认知、医学、生物标记物和心理社会数据，并对其进行整理和分析。

项目成果

Genetic variants in CETP increase risk of intracerebral hemorrhage.

• DOI: 10.1002/ana.24780
• 发表时间: 2016-11
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Anderson, Christopher D.;Falcone, Guido J.;Phuah, Chia-Ling;Radmanesh, Farid;Brouwers, H. Bart;Battey, Thomas W. K.;Biffi, Alessandro;Peloso, Gina M.;Liu, Dajiang J.;Ayres, Alison M.;Goldstein, Joshua N.;Viswanathan, Anand;Greenberg, Steven M.;Selim, Magdy;Meschia, James F.;Brown, Devin L.;Worrall, Bradford B.;Silliman, Scott L.;Tirschwell, David L.;Flaherty, Matthew L.;Kraft, Peter;Jagiella, Jeremiasz M.;Schmidt, Helena;Hansen, Bjorn M.;Jimenez-Conde, Jordi;Giralt-Steinhauer, Eva;Elosua, Roberto;Cuadrado-Godia, Elisa;Soriano, Carolina;van Nieuwenhuizen, Koen M.;Klijn, Catharina J. M.;Rannikmae, Kristiina;Samarasekera, Neshika;Salman, Rustam Al-Shahi;Sudlow, Catherine L.;Deary, Ian J.;Morotti, Andrea;Pezzini, Alessandro;Pera, Joanna;Urbanik, Andrzej;Pichler, Alexander;Enzinger, Christian;Norrving, Bo;Montaner, Joan;Fernandez-Cadenas, Israel;Delgado, Pilar;Roquer, Jaume;Lindgren, Arne;Slowik, Agnieszka;Schmidt, Reinhold;Kidwell, Chelsea S.;Kittner, Steven J.;Waddy, Salina P.;Langefeld, Carl D.;Abecasis, Goncalo;Willer, Cristen J.;Kathiresan, Sekar;Woo, Daniel;Rosand, Jonathan
• 通讯作者: Rosand, Jonathan

Association between carotid atheroma and cerebral cortex structure at age 73 years.

• DOI: 10.1002/ana.25324
• 发表时间: 2018-10
• 期刊: Annals of neurology
• 影响因子: 11.2
• 作者: Alhusaini S;Karama S;Nguyen TV;Thiel A;Bernhardt BC;Cox SR;Corley J;Taylor A;Evans AC;Star JM;Bastin ME;Wardlaw JM;Deary IJ;Ducharme S
• 通讯作者: Ducharme S

Cognitive function in early and later life is associated with blood glucose in older individuals: analysis of the Lothian Birth Cohort of 1936.

• DOI: 10.1007/s00125-018-4645-8
• 发表时间: 2018-09
• 期刊: Diabetologia
• 影响因子: 8.2
• 作者: Altschul DM;Starr JM;Deary IJ
• 通讯作者: Deary IJ

Coupled changes in hippocampal structure and cognitive ability in later life.

• DOI: 10.1002/brb3.838
• 发表时间: 2018-03
• 期刊: Brain and behavior
• 影响因子: 3.1
• 作者: Anblagan D;Valdés Hernández MC;Ritchie SJ;Aribisala BS;Royle NA;Hamilton IF;Cox SR;Gow AJ;Pattie A;Corley J;Starr JM;Muñoz Maniega S;Bastin ME;Deary IJ;Wardlaw JM
• 通讯作者: Wardlaw JM

Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study.

• DOI: 10.1016/j.neuroimage.2018.08.075
• 发表时间: 2018-09-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Alloza C;Cox SR;Blesa Cábez M;Redmond P;Whalley HC;Ritchie SJ;Muñoz Maniega S;Valdés Hernández MDC;Tucker-Drob EM;Lawrie SM;Wardlaw JM;Deary IJ;Bastin ME
• 通讯作者: Bastin ME