A flow cytometry facility for ocular regenerative medicine

用于眼再生医学的流式细胞术设备

• 批准号: MR/L012758/1
• 负责人: Robin Ali
• 金额: $ 85.96万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL012758%2F1
• 关键词: flow; cytometry; facility; ocular; regenerative

This funding will establish a UCL Institute of Ophthalmology flow cytometry facility to support the Institute's ocular regenerative medicine programme. The Institute is recognised internationally for its remarkably strong track record in delivery of novel biological therapies for eye disease and stem cell therapy in particular (e.g. first-in-man gene therapy, stem cell therapy for ocular surface disease, stem cell therapy for advanced Stargardt's, stem cell therapy for age-related macular degeneration [AMD] on target for 2013). An in-house cytometry facility with state-of-the-art equipment for analysis and sorting of stem and progenitor cells will to help to maintain UCL Institute of Ophthalmology as a world leading world centre for ocular cell transplantation.

这笔资金将建立一个UCL眼科研究所流式细胞仪设施，以支持该研究所的眼部再生医学计划。该研究所因其在眼科疾病和干细胞治疗的新型生物疗法方面的出色业绩而在国际上得到认可（例如，首次人体基因疗法，眼表疾病的干细胞疗法，晚期Stargardt的干细胞疗法，年龄相关性黄斑变性[AMD]的干细胞疗法，目标是2013年）。一个拥有最先进的干细胞和祖细胞分析和分选设备的内部细胞仪设施将有助于维持UCL眼科研究所作为世界领先的世界眼细胞移植中心的地位。

项目成果

Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.

• DOI: 10.1016/j.exer.2016.08.007
• 发表时间: 2016-10
• 期刊: EXPERIMENTAL EYE RESEARCH
• 影响因子: 3.4
• 作者: Liyanage, Sidath E.;Gardner, Peter J.;Ribeiro, Joana;Cristante, Enrico;Sampson, Robert D.;Luhmann, Ulrich F. O.;Ali, Robin R.;Bainbridge, James W.
• 通讯作者: Bainbridge, James W.

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

• DOI: 10.1242/dmm.022475
• 发表时间: 2016-04
• 期刊: Disease models & mechanisms
• 影响因子: 4.3
• 作者: Chu CJ;Gardner PJ;Copland DA;Liyanage SE;Gonzalez-Cordero A;Kleine Holthaus SM;Luhmann UF;Smith AJ;Ali RR;Dick AD
• 通讯作者: Dick AD

Augmenting Endogenous Levels of Retinal Annexin A1 Suppresses Uveitis in Mice.

• DOI: 10.1167/tvst.6.5.10
• 发表时间: 2017-09
• 期刊: Translational vision science & technology
• 影响因子: 3
• 作者: Gardner PJ;Yazid S;Ribeiro J;Ali RR;Dick AD
• 通讯作者: Dick AD

Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.

低氧诱导因素对于髓样细胞迁移到发炎的小鼠眼中是可剂量的。

• DOI: 10.1038/srep40830
• 发表时间: 2017-01-23
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Gardner PJ;Liyanage SE;Cristante E;Sampson RD;Dick AD;Ali RR;Bainbridge JW
• 通讯作者: Bainbridge JW

Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury.

• DOI: 10.3389/fimmu.2018.02023
• 发表时间: 2018
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Nauser CL;Howard MC;Fanelli G;Farrar CA;Sacks S
• 通讯作者: Sacks S