Investigation of the early growth response gene (Egr) 2 and 3 mediated regulatory programme in T cells

T 细胞中早期生长反应基因 (Egr) 2 和 3 介导的调控程序的研究

基本信息

  • 批准号:
    MR/N00096X/1
  • 负责人:
  • 金额:
    $ 61.6万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2015
  • 资助国家:
    英国
  • 起止时间:
    2015 至 无数据
  • 项目状态:
    已结题

项目摘要

Our heath relies on the normal function of the immune system. The function of the immune system is uniquely regulated in such a way that it can maintain a robust attack against pathogens, such as viruses, but remain tolerant of one's own tissues. Although the function of the immune system has been extensively studied, the mechanisms which cause the immune system to mistakenly attack one's own body or to permit the persistence of certain viruses, such as HIV, in our body are still unknown. More than 80 clinically distinct autoimmune diseases result from dysregulation of the immune system. Several are well known, including rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and lupus. Others are less familiar, including autoimmune hepatitis, Sjögren's syndrome, autoimmune ear disease, and pemphigus. Equally, more than 10 chronic infectious diseases, such as HIV and hepatitis C virus infection, result from a failure of our immune system to provide protection. Collectively, these diseases afflict an estimated 5 to 8 per cent of the population in the UK and worldwide. The social and financial burdens imposed by these chronic, debilitating diseases include poor quality of life, high health care costs, and substantial loss of productivity. Recently we discovered a unique function of two molecules, Egr2 and 3, in one type of white blood cells, T cells, which is essential for preventing the immune system from attacking self-tissues while promoting immune attacks on viruses. Removal of these two molecules from T cells from mice results in severe autoimmune diseases that are similar to human lupus diseases and these mice also fail to recover from virus infection. These findings were previously unknown and have been published in leading immunological journals such as 'The Journal of Immunology', 'The Journal of Experimental Medicine' and 'Immunity'. The proposed study aims to define the mechanisms by which Egr2 and 3 prevent T cells from attacking self-tissues but enhance their anti-virus function. The findings from the proposed study would not only provide a better conceptual understanding of immunological function, but importantly provide new strategies for the development of therapies for autoimmune and chronic infectious diseases.
我们的健康依赖于免疫系统的正常功能。免疫系统的功能以这样一种方式被独特地调节,即它可以保持对病原体(如病毒)的强大攻击,但对自己的组织保持耐受性。虽然免疫系统的功能已被广泛研究,但导致免疫系统错误地攻击自己的身体或允许某些病毒(如HIV)在我们体内持续存在的机制仍然未知。超过80种临床上不同的自身免疫性疾病是由免疫系统调节失调引起的。有几种是众所周知的,包括类风湿性关节炎、多发性硬化症、1型糖尿病和狼疮。其他不太熟悉,包括自身免疫性肝炎,干燥综合征,自身免疫性耳部疾病和天疱疮。同样,10多种慢性传染病,如艾滋病毒和丙型肝炎病毒感染,是由于我们的免疫系统未能提供保护造成的。总的来说,这些疾病折磨着英国和世界各地约5%至8%的人口。这些慢性、使人衰弱的疾病造成的社会和财政负担包括生活质量差、保健费用高和生产力的严重损失。最近,我们在一种类型的白色血细胞(T细胞)中发现了两种分子Egr 2和3的独特功能,这对于防止免疫系统攻击自身组织同时促进对病毒的免疫攻击至关重要。从小鼠T细胞中去除这两种分子会导致类似于人类狼疮疾病的严重自身免疫性疾病,并且这些小鼠也无法从病毒感染中恢复。这些发现以前是未知的,并已发表在领先的免疫学杂志,如“免疫学杂志”,“实验医学杂志”和“免疫”。这项研究旨在确定Egr 2和3阻止T细胞攻击自身组织但增强其抗病毒功能的机制。这项研究的结果不仅可以提供对免疫功能更好的概念性理解,而且重要的是为自身免疫性疾病和慢性感染性疾病的治疗提供了新的策略。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
  • DOI:
    10.1084/jem.20160553
  • 发表时间:
    2017-06-05
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Miao T;Symonds ALJ;Singh R;Symonds JD;Ogbe A;Omodho B;Zhu B;Li S;Wang P
  • 通讯作者:
    Wang P
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
  • DOI:
    10.1002/iid3.210
  • 发表时间:
    2018-06
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Omodho B;Miao T;Symonds ALJ;Singh R;Li S;Wang P
  • 通讯作者:
    Wang P
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Ping Wang其他文献

Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells.
Nkx3.1 的表达增强 PC3 人前列腺癌细胞中 17β-雌二醇的抗肿瘤作用。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Ping Wang;Ben Liu;Jin;Zhi;Q. Ma;Zhao
  • 通讯作者:
    Zhao
Cost-sensitive feature selection based on adaptive neighborhood granularity with multi-level confidence
基于多级置信度自适应邻域粒度的成本敏感特征选择
  • DOI:
    10.1016/j.ins.2016.05.025
  • 发表时间:
    2016-10
  • 期刊:
  • 影响因子:
    8.1
  • 作者:
    Hong Zhao;Ping Wang;Qing-Hua Hu
  • 通讯作者:
    Qing-Hua Hu
The facile synthesis of homoleptic phenylpyridazine iridium(III) complexes and their application in high efficiency OLEDs
均配苯基哒嗪铱(III)配合物的简便合成及其在高效OLED中的应用
  • DOI:
    10.1016/j.orgel.2019.105439
  • 发表时间:
    2019-12
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Man Chen;Li-Ding Wang;Yue Wang;Yue-Yue Zhou;Cheng-Gui Hu;Bi-Hai Tong;Zu-Qiang Bian;Lianshe Fu;Qian-Feng Zhang;Ping Wang
  • 通讯作者:
    Ping Wang
Structure and expression of sulfatase and sulfatase modifying factor genes in the diamondback moth, Plutella xylostella (L.)
小菜蛾 (Plutella xylostella (L.)) 硫酸酯酶和硫酸酯酶修饰因子基因的结构和表达
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Xiao-Li Ma;Wei-Yi He;Wei Chen;Xue-Jiao Xu;Wei-Ping Qi;Ming-Min Zou;Yan-Chun You;Simon W. Baxter;Ping Wang;Min-Sheng You
  • 通讯作者:
    Min-Sheng You
THE STUDY ON NOVEL MICROELECTRODE ARRAY CHIPS FOR THE DETECTION OF HEAVY METALS IN WATER POLLUTION
新型微电极阵列芯片检测水污染中重金属的研究

Ping Wang的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Ping Wang', 18)}}的其他基金

CRII: III: Towards Reasoning Augmented Searching for Domain-Specific Knowledge Screening
CRII:III:针对特定领域知识筛选的推理增强搜索
  • 批准号:
    2245907
  • 财政年份:
    2023
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
Collaborative Research: Cultivating Tomorrow's Innovators Through Exploring Planetary Images with Artificial Intelligence
合作研究:通过人工智能探索行星图像培养明天的创新者
  • 批准号:
    2314155
  • 财政年份:
    2023
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
CyberCorps Scholarship for Service: Excellence, Ethics, and Strategic Thinking
Cyber​​Corps 服务奖学金:卓越、道德和战略思维
  • 批准号:
    2234554
  • 财政年份:
    2023
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Continuing Grant
RAPID: 2018 Hurricane Season: Sedimentological and Morphological Characteristics of Hurricane Michael Induced Storm Deposits in Apalachicola Bay
RAPID:2018 年飓风季节:迈克尔飓风引发的阿巴拉契科拉湾风暴沉积物的沉积学和形态特征
  • 批准号:
    1904055
  • 财政年份:
    2018
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
BIGDATA: IA: Virtual Observatory of Innovation Communities and Ecosystems (VOICE): Advancing Big Data with Ecology Theory and Data Science
大数据:IA:创新社区和生态系统虚拟观测站(VOICE):利用生态理论和数据科学推进大数据
  • 批准号:
    1546404
  • 财政年份:
    2016
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
Collaborative Research: Bringing Problem Solving in the Field into the Classroom: Developing and Assessing Virtual Field Trips for Teaching Sedimentary and Introductory Geology
合作研究:将现场解决问题带入课堂:开发和评估沉积学和入门地质学教学的虚拟实地考察
  • 批准号:
    1044257
  • 财政年份:
    2011
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
RAPID: Emergency Field Investigation of Oil-Beach Interaction along the Alabama and Florida Beaches Following the BP Deepwater Horizon Oil Spill
RAPID:英国石油公司深水地平线漏油事件后,对阿拉巴马州和佛罗里达州海滩沿线的油滩相互作用进行紧急现场调查
  • 批准号:
    1041868
  • 财政年份:
    2010
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
DHB: Scalable Computational Analysis of the Diffusion of Technological Concepts
DHB:技术概念扩散的可扩展计算分析
  • 批准号:
    0729459
  • 财政年份:
    2007
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Standard Grant
CAREER: Study of Novel Interfacial Biocatalysis of Multienzyme Systems Self-Assembled at Organic-Aqueous Interfaces
职业:有机-水界面自组装多酶系统的新型界面生物催化研究
  • 批准号:
    0703999
  • 财政年份:
    2006
  • 资助金额:
    $ 61.6万
  • 项目类别:
    Continuing Grant

相似国自然基金

Crocin 抑制 Hartley 豚鼠早期骨关节炎发生的 作用机制研究
  • 批准号:
    TGD24H060003
  • 批准年份:
    2024
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
RIPK3蛋白及其RHIM结构域在脓毒症早期炎症反应和脏器损伤中的作用和机制研究
  • 批准号:
    82372167
  • 批准年份:
    2023
  • 资助金额:
    48.00 万元
  • 项目类别:
    面上项目
均相液相生物芯片检测系统的构建及其在癌症早期诊断上的应用
  • 批准号:
    82372089
  • 批准年份:
    2023
  • 资助金额:
    48.00 万元
  • 项目类别:
    面上项目
环境抗雄激素干预AR/TGFB1I1致尿道下裂血管内皮细胞发育异常的机制及其“预警信号”在早期诊断中的价值
  • 批准号:
    82371605
  • 批准年份:
    2023
  • 资助金额:
    46.00 万元
  • 项目类别:
    面上项目
增强子在小鼠早期胚胎细胞命运决定中的功能和调控机制研究
  • 批准号:
    82371668
  • 批准年份:
    2023
  • 资助金额:
    52.00 万元
  • 项目类别:
    面上项目
BNIP-2调控E-cadherin细胞内分选运输的机制研究
  • 批准号:
    32100540
  • 批准年份:
    2021
  • 资助金额:
    20.0 万元
  • 项目类别:
    青年科学基金项目
玉米Edk1(Early delayed kernel 1)基因的克隆及其在胚乳早期发育中的功能研究
  • 批准号:
    31871625
  • 批准年份:
    2018
  • 资助金额:
    60.0 万元
  • 项目类别:
    面上项目
膀胱癌高表达基因UPK3A的筛选、鉴定和相关研究
  • 批准号:
    81101922
  • 批准年份:
    2011
  • 资助金额:
    23.0 万元
  • 项目类别:
    青年科学基金项目
精神创伤相关的抑郁症HPA轴功能与相关脑区磁共振特征研究
  • 批准号:
    81171286
  • 批准年份:
    2011
  • 资助金额:
    58.0 万元
  • 项目类别:
    面上项目
早年心理应激对大鼠抑郁样行为及突触可塑性的影响
  • 批准号:
    81171284
  • 批准年份:
    2011
  • 资助金额:
    58.0 万元
  • 项目类别:
    面上项目

相似海外基金

Mentoring Underrepresented Researchers in Diabetes and Pregnancy Investigation
指导糖尿病和妊娠调查中代表性不足的研究人员
  • 批准号:
    10796029
  • 财政年份:
    2023
  • 资助金额:
    $ 61.6万
  • 项目类别:
Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition
午睡过渡期间睡眠、记忆和大脑发育的纵向研究
  • 批准号:
    10659988
  • 财政年份:
    2023
  • 资助金额:
    $ 61.6万
  • 项目类别:
Investigation of a new sequential multiple hit model to examine risk and resilience in a prospective longitudinal cohort of children in Ghana
研究一种新的连续多重打击模型,以检查加纳儿童前瞻性纵向队列的风险和复原力
  • 批准号:
    10373248
  • 财政年份:
    2022
  • 资助金额:
    $ 61.6万
  • 项目类别:
Examining distinct and shared mechanisms underlying arithmetic and reading development through behavioral and neural measures: alongitudinal investigation
通过行为和神经测量来检查算术和阅读发展背后的独特和共享机制:纵向调查
  • 批准号:
    10480928
  • 财政年份:
    2021
  • 资助金额:
    $ 61.6万
  • 项目类别:
Examining distinct and shared mechanisms underlying arithmetic and reading development through behavioral and neural measures: alongitudinal investigation
通过行为和神经测量来检查算术和阅读发展背后的独特和共享机制:纵向调查
  • 批准号:
    10311607
  • 财政年份:
    2021
  • 资助金额:
    $ 61.6万
  • 项目类别:
Examining distinct and shared mechanisms underlying arithmetic and reading development through behavioral and neural measures: alongitudinal investigation
通过行为和神经测量来检查算术和阅读发展背后的独特和共享机制:纵向调查
  • 批准号:
    10626960
  • 财政年份:
    2021
  • 资助金额:
    $ 61.6万
  • 项目类别:
A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
阴道宏基因组和代谢组及其在自发性早产中的作用的大规模研究
  • 批准号:
    10665611
  • 财政年份:
    2021
  • 资助金额:
    $ 61.6万
  • 项目类别:
A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
阴道宏基因组和代谢组及其在自发性早产中的作用的大规模研究
  • 批准号:
    10280132
  • 财政年份:
    2021
  • 资助金额:
    $ 61.6万
  • 项目类别:
A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
阴道宏基因组和代谢组及其在自发性早产中的作用的大规模研究
  • 批准号:
    10461073
  • 财政年份:
    2021
  • 资助金额:
    $ 61.6万
  • 项目类别:
Biocultural investigation of maternal adversity on gene expression and DNA methylation in the placenta
母体逆境对胎盘基因表达和 DNA 甲基化影响的生物文化研究
  • 批准号:
    10397565
  • 财政年份:
    2019
  • 资助金额:
    $ 61.6万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了