RAPID THAWING OF FROZEN BLOOD AND BLOOD COMPONENTS

冷冻血液和血液成分的快速解冻

• 批准号: 2867664
• 负责人: KENNETH L CARR
• 金额: $ 9.92万
• 依托单位: MICROWAVE MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867664
• 关键词: biomedical equipment development; blood preservation; cryopreservation; electromagnetic radiation; heat; microwave radiation; physical separation; technology /technique development

This proposal defines the need for the development of a device involving safe, rapid and uniform heating to thaw frozen blood and blood components. This device would result in a therapeutically effective product that would reduce the risk of contamination and damage, and significantly increase allowable storage time. Rapid thawing (i.e., less than 5 minutes) is essential. The proposed rapid thawing technique employs an active microwave array in conjunction with radiometric sensing. Each element of the array is, basically, a dual-mode transducer allowing simultaneous microwave heating and radiometric temperature sensing, and further allowing independent control of power at each element. The development and integration of the multi-element array will include the capability to monitor and control the temperature of the entire blood unit. This device for the rapid thawing of frozen blood and blood components may be integrated into a total closed-cell preparation system which includes other functions, such as sterile docking, cell washing and in-line warming. The device is consistent with the NIH objective of developing "equipment and procedures for the collection, separation, processing, preservation, storage and distribution of blood and blood components." PROPOSED COMMERCIAL APPLICATIONS: This device would result in improved health care at significant cost savings since blood components would no longer be thawed well in advance of the need.

该提案定义了开发一种涉及安全、快速和均匀加热以解冻冷冻血液和血液成分的器械的需求。该装置将产生治疗有效的产品，其将降低污染和损坏的风险，并显著增加允许的储存时间。快速解冻（即，少于5分钟）是必要的。拟议的快速解冻技术采用了主动微波阵列与辐射传感。阵列的每个元件基本上是双模换能器，其允许同时进行微波加热和辐射温度感测，并且还允许独立控制每个元件处的功率。多元件阵列的开发和集成将包括监测和控制整个血液单元温度的能力。这种用于快速解冻冷冻血液和血液成分的装置可以集成到包括其他功能（例如无菌对接、细胞洗涤和在线加热）的全封闭细胞制备系统中。该器械符合NIH的目标，即开发“血液和血液成分的采集、分离、处理、保存、储存和分配设备和程序”。“拟议的商业应用：该设备将导致改善医疗保健，节省大量成本，因为血液成分将不再在需要之前解冻。