BRAIN TEMPERATURE MONITORING IN NEONATES

新生儿脑温度监测

• 批准号: 6882239
• 负责人: KENNETH L CARR
• 金额: $ 9.88万
• 依托单位: MERIDIAN MEDICAL SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-15 至 2005-10-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882239
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; body temperature; brain; brain disorders; clinical biomedical equipment; cryotherapy; microwave radiation; newborn human (0-6 weeks); patient monitoring device; phantom model; thermometry

DESCRIPTION (provided by applicant): Hypoxic-ischemic encephalopathy (HIE) represents a serious problem in newborns, occurring in 3-9 of every 1000 term infants, with about half of these HIE babies dying or suffering life-long severe handicaps, such as mental retardation or cerebral palsy. Current efforts to reduce the effects of HIE by hypothermia (cooling) have been hampered by the lack of a reliable noninvasive method of monitoring the infant's brain temperature during the hypothermic treatment, which lasts about 48 hours. This proposal will evaluate temperature monitoring using noninvasive dual frequency microwave radiometry of the skull. The Phase I objectives will include: 1) Design of a dual frequency waveguide transducer, 2) Investigation of printed structures for the dual frequency transducer, 3) Development of a sterile disposable interface, 4) Development of a transducer placement monitor to insure proper placement, and 5) Construction of a dielectric phantom and evaluation of thermal patterns using noninvasive radiometry and invasive thermometry. The technical challenge of Phase I lies in the development of the components needed to produce a system which can reliably detect and monitor temperature in the brain tissue, at a depth of at least 15mm, and development of an appropriate model (phantom) and the verification of the EM modeling data.

描述（由申请人提供）： 新生儿缺氧缺血性脑病（HIE）是新生儿中的严重问题，每1000名足月婴儿中有3-9名发生，其中约一半的HIE婴儿死亡或患有终身严重残疾，如智力迟钝或脑瘫。目前通过低温（冷却）来减少HIE影响的努力受到了缺乏可靠的非侵入性方法的阻碍，该方法可以在持续约48小时的低温治疗期间监测婴儿的大脑温度。该提案将评估使用颅骨的非侵入性双频微波辐射测量的温度监测。第一阶段的目标将包括：1）双频波导换能器的设计，2）双频换能器的印刷结构的研究，3）无菌一次性接口的开发，4）换能器放置监测器的开发，以确保正确放置，以及5）介电体模的构建和使用无创辐射测量和有创温度测量的热模式的评价。第一阶段的技术挑战在于开发所需的组件，以产生一个系统，该系统可以可靠地检测和监测脑组织中的温度，深度至少为15 mm，并开发适当的模型（体模）和验证EM建模数据。