BRAIN TEMPERATURE MONITORING IN NEONATES (PHASE II)

新生儿脑温度监测（第二阶段）

• 批准号: 7334711
• 负责人: KENNETH L CARR
• 金额: $ 37.05万
• 依托单位: MERIDIAN MEDICAL SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-03 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7334711
• 关键词: Algorithms; Animal Testing; Brain; Cerebral Palsy; Cessation of life; Clinical Research; Compatible; Complication; Computer software; Depth; Detection; Development; Disabled Persons; Feasibility Studies; Frequencies; Goals; Hour; Infant; Injury; Knowledge; Learning; Life; Logic; Mental Retardation; Methods; Monitor; Newborn Infant; Output; Oxygen; Patients; Phase; Placement; Radiometry (Microwave); Research; Schedule; Skin; Sterility; System; Temperature; Time; Transducers; United States; animal data; base; brain metabolism; database design; design; design and construction; disability; evaluation/testing; experience; handicapping condition; infant monitoring; injured; natural hypothermia; neonatal hypoxic-ischemic brain injury; neonate; programs; sensor; size

DESCRIPTION (provided by applicant): Hypoxic-ischemic encephalopathy (HIE) represents a serious problem in newborns, occurring in 3-9 of every 1,000 term infants, with about half of these HIE babies dying or suffering life-long severe handicaps, such as mental retardation or cerebral palsy. Current efforts to reduce the effects of HIE by hypothermia (cooling) have been hampered by the lack of a reliable noninvasive method of monitoring the infant's brain temperature during the hypothermic treatment, which lasts about 48 hours. The primary objective of this Phase I feasibility study was to evaluate Passive Microwave Radiometry (PMR) for monitoring intracranial temperature in neonates. The Phase I program has been successfully completed. The significant challenge of the overall program occurs in Phase II involving the integration of the radiometric receivers into the transducers and developing the logic and circuitry required to combine the two radiometric outputs to determine temperature at depth. The goal of the Phase II program is to develop an affordable system for the reliable and continuous monitoring of intracranial temperature in neonates. 7. Project Narrative Two to four of every 1000 babies delivered in the United States experience an obstetrical complication resulting in asphyxial injury to the brain leading to the development of cerebral palsy, mental retardation or even death. Recent clinical studies have shown that hypothermia decreases the injured brain's metabolism and oxygen requirements, and can significantly decrease the chances of physical disability and death. Although promising, hypothermia is an evolving therapy and there is much to learn regarding the optimal degree and duration of hypothermia. Knowledge of exact brain temperature is needed before these important questions can be adequately answered.

描述(申请人提供)：新生儿缺氧缺血性脑病(HIE)是一种严重的新生儿问题，每1000名足月婴儿中有3-9名发生，其中约一半死亡或遭受终身严重残疾，如智力低下或脑瘫。目前通过低温(降温)来减少HIE影响的努力受到了阻碍，因为在持续约48小时的低温治疗期间，缺乏可靠的非侵入性方法来监测婴儿的大脑温度。这项第一阶段可行性研究的主要目标是评估被动微波辐射测量(PMR)在监测新生儿颅内温度方面的作用。第一阶段计划已圆满完成。整个计划的重大挑战出现在第二阶段，涉及将辐射接收器集成到换能器中，并开发组合两个辐射输出以确定深度温度所需的逻辑和电路。第二阶段计划的目标是开发一种负担得起的系统，用于可靠和连续地监测新生儿的颅内温度。7.项目叙述在美国分娩的婴儿中，每1000人中就有2至4人经历产科并发症，导致大脑窒息损伤，导致脑瘫、智力低下甚至死亡。最近的临床研究表明，低温降低了受损大脑的新陈代谢和氧气需求，并可以显著降低身体残疾和死亡的机会。尽管很有希望，但低温是一种不断发展的治疗方法，关于低温的最佳程度和持续时间，还有很多需要学习的地方。在充分回答这些重要问题之前，需要了解准确的大脑温度。